Target List
Leukemia
Acute Lymphoblastic Leukemia (ALL)
ABL1BRAFBTKCDKN2A (P16INK4A)CREBBP (CBP)ETV6FBXW7FLT3HRASJAK1JAK2JAK3KMT2AKRASMYCNOTCH1NRASPTENPTPN11RUNX1 (AML1)SF3B1TP53 (p53)
Acute Myeloid Leukemia (AML)
ASXL1ATRXBRCA1BRCA2CBLBCBLCCEBPADNMT3AETV6FLT3GATA1GATA2GNASHRASIDH1IDH2JAK2KIT (CD117)KMT2AKRASMTORNPM1NRASPDGFRAPTPN11RUNX1 (AML1)SF3B1SMC1ATET2TP53 (p53)U2AF1WT1
Acute Promyelocytic Leukemia (APML; APL)
CEBPANPM1RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1CBLCEBPAEZH2FLT3JAK2KRASNPM1NRASRUNX1 (AML1)SETBP1SRSF2TET2U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRXBCL2BRAFCBLBGNASGNB1MYD88NOTCH1NRASPTPN11SF3B1TP53 (p53)XPO1
Chronic Myeloid Leukemia (CML)
ABL1ASXL1BCORBRAFCBLCREBBP (CBP)DNMT3AEZH2IDH1IDH2JAK2KRASNPM1NRASRUNX1 (AML1)TET2TP53 (p53)WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1BCORBCORL1CBLCEBPADNMT3AEZH2FLT3IDH1IDH2JAK2KIT (CD117)KRASMPLNF1NPM1NRASPHF6PTPN11RUNX1 (AML1)SETBP1SF3B1SRSF2STAG2TET2TP53 (p53)U2AF1ZRSR2
Hairy Cell Leukemia
BRAFTP53 (p53)
Juvenile Myelomonocytic Leukemia
CBLKRASNRASPTPN11
Lymphomas
Acute Lymphocytic Lymphomas
BTKCDKN2A (P16INK4A)MYCNOTCH1SF3B1TP53 (p53)
B Cell Lymphomas
BCL6BRAFCHEK2 (RAD53)EZH2MYD88TP53 (p53)
Burkitt Lymphomas
CBLBGNA13MTORMYC
Diffuse Large B Cell Lymphomas
B2MBCL2CBLBGNA13KMT2DMTORPIM1SOCS1TNFAIP3
Follicular Lymphomas
ARID1ABCL2CARD11CREBBP (CBP)EZH2KMT2D
Mantle Cell Lymphomas
ATM
Marginal Zone Lymphomas
MYD88TNFAIP3TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
TNFAIP3
Non-Hodgkin Lymphomas
BRAFNRASPIK3CA (p110-alpha)TP53 (p53)
Primary Cutaneous Lymphomas
CD79BMYD88
Small Lymphocytic Lymphomas
ATRXBCL2CBLBGNASXPO1
T Cell Lymphomas
ATMCBLBDNMT3AIDH1IDH2JAK1JAK3RHOASTAT3STAT5BTET2
Myelodysplastic Syndromes & Myeloproliferative Neoplasms
Myelodysplastic Syndromes
ASXL1ATRXBCORBCORL1CALRCBLCEBPACSF3R (GM-CSFR)DNMT3AETV6EZH2FLT3GATA2GNASGNB1IDH1IDH2JAK2JAK3KIT (CD117)KRASMPLNF1NPM1NRASPHF6PPM1DPTPN11RAD21RUNX1 (AML1)SETBP1SF3B1SMC3SRSF2STAG2STAT3TET2TP53 (p53)U2AF1WT1ZRSR2
Myeloproliferative Neoplasms
ASXL1CALRCBLDNMT3AEZH2IDH1IDH2JAK2MPLRUNX1 (AML1)SF3B1SRSF2TP53 (p53)U2AF1
Other Myeloid Neoplasms
Essential Thrombocythemia
ASXL1CBLIDH2JAK2MPLSF3B1TET2TP53 (p53)
Multiple Myeloma
ATMBARD1BRAFBRCA1BRCA2BRIP1CHEK1CHEK2 (RAD53)EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCLFGFR3IDH1IDH2KIT (CD117)KRASMETNRASPALB2PDGFRARAD51BRAD51CRAD51DRETTP53 (p53)
Plasma Cell Myeloma
HRASMTOR
Polycythemia Vera
ASXL1DNMT3AEZH2IDH1JAK2NRASTET2TP53 (p53)
Primary Myelofibrosis
ASXL1CBLDNMT3AEZH2IDH1IDH2JAK2MPLNF1NRASSETBP1SF3B1SRSF2TET2TP53 (p53)
Systemic Mastocytosis
ASXL1CBLDNMT3AETV6EZH2IDH2JAK2KIT (CD117)KRASNPM1NRASRUNX1 (AML1)SETBP1SF3B1SRSF2TET2U2AF1
Waldenstrom Macroglobulinemia
MYD88