Target List
JAK / STAT Signaling
Janus Kinases
JAK1JAK2JAK3TYK2
STAT Family Members
STAT1STAT2STAT3STAT4STAT5ASTAT5BSTAT6
JAK / STAT Signaling Regulators
PIAS1PIAS2PRLPTPN1 (PTP1B)PTPRCSOCS1SOCS2SOCS3SOCS4SOCS5
Cell Surface Receptors
CSF1REGFR (ERBB1)EPORF2R (PAR1)GHRIFNAR1IFNGR1IL10RAIL2RA (CD25)IL2RGIL4R (CD124)IL6ST (GP130)INSRMPLPDGFRASH2B1
SH3 / SH2 Adaptor Proteins
CRKGRB2SRCSTAM
STAT-Interacting Transcription Factors & Regulators
Transcriptional Regulation
HMGA1SMAD3 (MADH3)SPI1
Transcription Factors
JUNBSP1USF1
Transcriptional Coactivators & Corepressors
JUNBPIAS1SMAD1 (MADH1)SMAD5 (MADH5)SP1YY1
Other Transcription Factors & Regulators
CEBPBCRKGATA3IRF1IRF9JUNMYCNFKB1NR3C1 (GRL)SMAD2 (MADH2)SMAD4 (MADH4)
STAT-Induced
STAT1-Induced
CXCL9 (MIG)IRF1JUNBNOS2 (iNOS)
STAT3-Induced
A2MBCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CCND1CDKN1A (p21CIP1, WAF1)CEBPDCRPFASIRF1LRG1MCL1MYCSOCS1SOCS3
STAT4-Induced
FCGR1AIFNGIRF1MYC
STAT5-Induced
BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CCND1CDKN1A (p21CIP1, WAF1)IL2RA (CD25)IRF1OSM
STAT6-Induced
FCER2GATA3IL4IL4R (CD124)
STAT1 / STAT2 / p48 Induced
ISG15OAS1
Apoptosis
AKT1BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CDKN1A (p21CIP1, WAF1)F2 (Thrombin)F2R (PAR1)FASIL2RA (CD25)MCL1NFKB1PRLRSTAT1
Cell Growth and / or Maintenance
Cell Cycle
CCND1CDKN1A (p21CIP1, WAF1)EGFR (ERBB1)F2 (Thrombin)F2R (PAR1)IL2RA (CD25)IRF1JAK2MYCSTAT1
Cell Growth
A2MEGFR (ERBB1)GHRIFNGIL4INSROSMSOCS1SOCS2SOCS3SOCS4SOCS5
Cell Proliferation
CSF1RIL2RGIL4MPLOSMPDGFRASMAD3 (MADH3)
Cell Differentiation
IL20IL4NOS2 (iNOS)SOCS2SOCS5
Immune Response
Acute-Phase Response
CEBPBCRPF2 (Thrombin)STAT3
Humoral Immune Response
CSF1RFCER2IL4NFKB1YY1
Inflammatory Response
CEBPBCRPCXCL9 (MIG)IL20NFKB1NOS2 (iNOS)NR3C1 (GRL)
Other Immune Response Genes
CXCL9 (MIG)FASFCGR1AIFNGIL2RA (CD25)IL2RGIL4R (CD124)IL6ST (GP130)IRF1IRF9ISG15OAS1OSMPRLRPTPN11STUB1