Target List
Fungal Pattern Recognition Receptors (PRRs)
Beta-Glycan Responsive
CD36CD5CLEC7A (DECTIN1)ITGAMITGB2SCARF1TLR2
Mannose / Chitin Responsive
CD207CD209CHIACLEC6A (DECTIN2)MRC1TLR2TLR4
Other Fungal Pattern Recognition Receptors (PRRs)
COLEC12NLRP3NPTX1PTX3TLR9
Signal Transduction
Dectin-1 Signaling
BCL10CARD9CLEC7A (DECTIN1)MALT1PLCG2RAF1SYK
NFκB Signaling
BCL10CARD9CASP1 (ICE)CASP8 (FLICE)CD40 (TNFRSF5)IKBKB (IKKβ)IL10IL1BIRAK1IRAK4MALT1MAP3K7 (TAK1)NFKB1NFKBIA (IκBα, MAD3)STAT1TNF
Toll-Like Receptor (TLR) Signaling
CASP8 (FLICE)CD14FOSIRAK1IRAK4ITGB2JUNMAP2K4 (MKK4, JNKK1)MAP3K7 (TAK1)MAPK14 (p38ALPHA)MAPK8 (JNK1)MYD88NFKB1TIRAPTLR2TLR4TLR9TRAF6
Complement Signaling
C3C5AR1 (GPR77)ITGAMITGB2LYNMBL2SYK
NOD-Like Receptor (NLR) Signaling
CARD9CASP1 (ICE)NLRP3PYCARD (TMS1, ASC)
Inflammation
C3CCL2 (MCP-1)CCL20 (MIP-3A)CCL5 (RANTES)CCR1CD14CD40 (TNFRSF5)CLEC7A (DECTIN1)CXCL1 (GRO1, GROa, SCYB1)CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL2 (GRO2, GROb, SCYB2)CXCL9 (MIG)F3FOSIL10IL1AIL1BIL2IL23AIL6CXCL8 (IL8)ITGB2LYNMBL2MYD88NFKB1PTGS2 (COX2)TIRAPTLR2TLR4TLR9TNF
Phagocytosis
C3CD14CD36CLEC7A (DECTIN1)COLEC12FCGR1AFCN1MBL2SFTPD
Genes Responsive to Specific Pathogenic Fungi
Candida albicans
CCL2 (MCP-1)CCL20 (MIP-3A)CCL5 (RANTES)CCR1CD14CD209CD83CLEC6A (DECTIN2)CLEC7A (DECTIN1)CSF2 (GM-CSF)CSF3 (GCSF)CXCL1 (GRO1, GROa, SCYB1)CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL2 (GRO2, GROb, SCYB2)CXCL9 (MIG)FCGR1AFCGR3AIFNGIL12BIL18IL1AIL1BIL1R1IL23AIL6CXCL8 (IL8)MYD88NFKB1PTGS2 (COX2)SOCS3TLR2TNF
Aspergillus fumigatus
C3CASP1 (ICE)CASP8 (FLICE)CCL2 (MCP-1)CCL20 (MIP-3A)CCL5 (RANTES)CCR1CD14CD40 (TNFRSF5)CD83CLEC6A (DECTIN2)CLEC7A (DECTIN1)CSF2 (GM-CSF)CSF3 (GCSF)CXCL1 (GRO1, GROa, SCYB1)CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL2 (GRO2, GROb, SCYB2)CXCL9 (MIG)F2RL1 (PAR2)F3FCGR1AFCGR2AFCN1IFNGIL10IL12AIL12BIL18IL1AIL1BIL1R1IL6CXCL8 (IL8)JUNMALT1MAPK14 (p38ALPHA)MBL2MYD88NFKBIA (IκBα, MAD3)PTGS2 (COX2)PTPN6PTX3SFTPDSOCS3ST3GAL5STAT1SYKTLR2TLR4TLR9TNF
Cryptococcus neoformans
C3CD5CCL2 (MCP-1)CD40 (TNFRSF5)SOCS3