Target List
Induction of Apoptosis
Death Domain Receptors
Casp8ap2Diablo (Smac)FaddLOC103694380 (Tnf)Tnfrsf10b (QuantiNova Symbol: AABR07018323.1)
DNA Damage & Repair
CideaCidebLOC100909750 (Abl1)Tp53 (p53)Tp73
Extracellular Apoptotic Signals
Casp8ap2Cflar (Casper)Dapk1
Other Pro-Apoptotic Genes
Akt1Apaf1BadBak1BaxBcl10Bcl2l11BidBikBnip3BokCasp1 (Ice)Casp12Casp14Casp2Casp3Casp4Casp8 (Flice)CycsDffaDffbFasFaslgGadd45aLOC103689977 (Casp6)Lta (Tnfb)Mapk1 (Erk2)Pycard (Tms1, Asc)Tnfsf10 (Trail)Tp53bp2Tp63TraddTraf3
Anti-Apoptotic
Akt1Anxa5Api5AvenBag1BaxBcl2Bcl2a1 (Bfl-1, A1)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l2Birc3 (c-IAP1)Birc5Bnip2Bnip3Cd40lgCflar (Casper)Dad1Dapk1FaimFasIl10LOC103694380 (Tnf)Mapk8ip1 (JIP1)Naip6 (QuantiNova Symbol: AC135826.1)Nfkb1Nol3PolbPrdx2PrlrSphk2Xiap
Regulation of Apoptosis
Negative Regulation of Apoptosis
Anxa5Bag1Bcl10Bcl2Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l2BfarBirc2 (c-IAP2)Birc3 (c-IAP1)Bnip2Bnip3Card10Casp3Cd40lgCflar (Casper)CideaDapk1DffaFasNol3Tp53 (p53)Tp73Xiap
Positive Regulation of Apoptosis
BadBak1BaxBidBnip3Casp1 (Ice)Casp14Casp2Casp4Casp8 (Flice)Cd40CidebFaddFaslgLOC100909750 (Abl1)LOC103689977 (Casp6)LOC103694380 (Tnf)LtbrNod1Pycard (Tms1, Asc)Ripk2Tnfrsf10b (QuantiNova Symbol: AABR07018323.1)Tnfsf10 (Trail)Tnfsf12Tp53 (p53)Tp53bp2Traf2Traf3
Death Domain Receptors
Dapk1FaddNfkb1Tnfrsf10b (QuantiNova Symbol: AABR07018323.1)Tnfrsf11b (Opg)Tnfrsf1a (Tnfr1)Tnfrsf1bTradd
Caspases & Regulators
Caspases
Casp1 (Ice)Casp12Casp14Casp2Casp3Casp4Casp7Casp8 (Flice)Casp9Cflar (Casper)LOC103689977 (Casp6)Pycard (Tms1, Asc)
Caspase Activation
Aifm1BaxCasp1 (Ice)Casp8ap2Casp9Nod1Pycard (Tms1, Asc)Tnfrsf10b (QuantiNova Symbol: AABR07018323.1)Tp53 (p53)
Caspase Inhibition
Birc5Xiap