Target List
TNF Superfamily Members
Induction of Apoptosis
FASLG (TNFSF6)LTA (TNFB)TNFSF10 (TRAIL)TNFSF14TNFSF8
Caspase Activation
TNFSF15
Caspase Inhibition
TNFSF14
Anti-Apoptotic
CD40LGTNFTNFSF18
Other Apoptosis Genes
CD70TNFSF9
Inflammatory Response
CD40LGTNF
NFκB Signaling
FASLG (TNFSF6)TNFTNFSF10 (TRAIL)TNFSF14TNFSF15
Other TNF Superfamily Members
LTBPGLYRP1PSMG2TNFSF11 (RANKL)TNFSF12TNFSF13TNFSF13BTNFSF4 (OX40L)
TNF Receptor Superfamily Members
Induction of Apoptosis
CD27 (TNFRSF7)FASTNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF19TNFRSF25 (DR3)TNFRSF9TRADD
Caspase Activation
TNFRSF10A (TRAIL-R)TNFRSF10B (DR5)
Caspase Inhibition
CD27 (TNFRSF7)
Anti-Apoptotic
CD27 (TNFRSF7)FASTNFRSF10DTNFRSF18TNFRSF6B
Other Apoptosis Genes
CD40 (TNFRSF5)LTBRNGFRTNFRSF10CTNFRSF11B (OPG)TNFRSF12ATNFRSF14TNFRSF1A (TNFR1)TNFRSF1BTNFRSF21
Inflammatory Response
CD40 (TNFRSF5)TNFRSF1A (TNFR1)
NFκB Signaling
CD27 (TNFRSF7)CD40 (TNFRSF5)EDA2RLTBRTNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF1A (TNFR1)TRADD
JNK / p38 Signaling
CD27 (TNFRSF7)EDA2RTNFRSF19
Other TNF Receptor Superfamily Members
RELTTNFRSF11A (RANK)TNFRSF13BTNFRSF13CTNFRSF17TNFRSF4 (OX40)TNFRSF8
TNFR1 Signaling
Induction of Apoptosis
CASP3CRADDFADDTRADD
Caspases
CASP2CASP3CASP8 (FLICE)
Anti-Apoptotic
BAG4CASP2TNF
Other Apoptosis Genes
DFFAPAK1TNFRSF1A (TNFR1)TRAF2
Inflammatory Response
TNFTNFRSF1A (TNFR1)
NFκB Signaling
CASP8 (FLICE)FADDTNFTNFRSF1A (TNFR1)TRADD
JNK / p38 Signaling
MAP2K4 (MKK4, JNKK1)MAPK8 (JNK1)PAK1
Transcriptional Regulation
JUNPARP1 (ADPRT1)RB1TNFTNFRSF1A (TNFR1)
Other TNFR1 Signaling Genes
AGFG1ARHGDIBCADLMNALMNB1LMNB2MADDMAP3K1 (MEKK1)MAP3K7 (TAK1)PAK2PRKDCSPTAN1
TNFR2 Signaling
Induction of Apoptosis
IKBKGLTA (TNFB)TRAF3
Anti-Apoptotic
NFKB1TNFAIP3
Other Apoptosis Genes
NFKBIA (IκBα, MAD3)TNFRSF1BTRAF1TRAF2
Inflammatory Response
NFKB1
NFκB Signaling
CHUK (IKKα)IKBKB (IKKβ)IKBKGNFKBIA (IκBα, MAD3)TNFAIP3
Transcriptional Regulation
IKBKB (IKKβ)IKBKGNFKB1NFKBIA (IκBα, MAD3)
Other TNFR2 Signaling Genes
AGFG1DUSP1 (PTPN16)ELP1MAP3K1 (MEKK1)