Target List
Insulin Receptor-Associated Proteins
Insulin & Receptors
INSINSL3IRS1IRS2IRS4SORBS1
Insulin-Like Growth Factors & Receptors
IGF1RIGF2IGFBP1
SH3 / SH2 Adaptor Proteins
CBLGAB1GRB2IRS4NCK1
Other Insulin Receptor-Associated Proteins
CAP1DOK1DOK2DOK3FRS2FRS3INSRPDPK1PPP1CAPTPN1 (PTP1B)PTPRFSHC1
PI3 Kinase Signaling
PI3 Kinase Canoncial Pathway Genes
AKT1AKT2AKT3EIF2B1EIF4EBP1 (4E-BP1)GSK3AGSK3BMTORPDPK1PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PIK3R2 (p85-BETA)PRKCGPRKCIPRKCZ
PI3 Kinase Signaling Target Genes
BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)DUSP14G6PCHK2IGFBP1PCK2SERPINE1 (PAI-1)SLC2A4 (GLUT4)SREBF1UCP1VEGFA
MAP Kinase Signaling
MAP Kinase Canoncial Pathway Genes
ARAFBRAFEIF2B1GRB2HRASMAP2K1MAPK1 (ERK2)RAF1RPS6KA1RRASRRAS2SHC1SOS1
MAP Kinase Signaling Target Genes
ANGBCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)ERCC1FOSLDLRNOS2 (iNOS)UCP1
Primary Insulin Signaling Target Genes
CEBPACEBPBFOSJUNLEP (Leptin)PRL
Secondary Insulin Signaling Effector Target Genes
NPYPCK2SLC2A1SLC2A4 (GLUT4)TG
PPARγ Targets
ACOX1ADRB3AEBP1CAP1CEBPACEBPBPCK2PPARGRETN
SREBP1 Targets
ACACAFBP1G6PCGCKPCK2PKM
Carbohydrate Metabolism
Glucose Metabolism
FBP1G6PCGCKHK2INSIRS2PCK2PKMSLC2A1SLC2A4 (GLUT4)SORBS1
Glycogen Metabolism
G6PCGSK3BPPP1CA
Other Carbohydrate Metabolism Genes
ADRB3GPD1INSR
Lipid Metabolism
Cholesterol Metabolism
LDLRSREBF1
Fatty Acid Metabolism
ACACAACOX1FASN
Lipid Transport
LDLRSORBS1
Other Lipid Metabolism Genes
ARAFBRAFINSLEP (Leptin)PPARGPRKCGPRKCIPRKCZRAF1SHC1
Protein Metabolism
Protein Phosphatases
DUSP14PPP1CAPTPN1 (PTP1B)PTPRF
Protein Kinases
AKT1AKT2AKT3ARAFBRAFGSK3AGSK3BIGF1RINSL3INSRMAP2K1MAPK1 (ERK2)PDPK1PRKCGPRKCIPRKCZRAF1RPS6KA1
Protein Biosynthesis
ANGEIF2B1EIF4EBP1 (4E-BP1)LDLRPPP1CA
Protein Transport
PRKCIRRAS2
Other Protein Metabolism Genes
AEBP1CBLDOK1DOK2FRS2GAB1IRS1NOS2 (iNOS)SORBS1VEGFA
Transcription Factors & Regulators
Transcriptional Regulation
CEBPACEBPBFOSJUNPPARGSREBF1
Transcription Factors
AEBP1CBLCEBPACEBPBFOSJUNPPARGSREBF1
Cell Growth & Differentiation
Cell Cycle
HK2HRASIGF1RIGF2KRASMAPK1 (ERK2)MTORVEGFA
Cell Proliferation
GAB1IGF1RIGF2IRS2NCK1NPYPRLRAF1SHC1VEGFA
Growth Factors & Receptors
GAB1GRB2IGF1RIGF2IGFBP1INSRSHC1VEGFA
Cell Differentiation
NOS2 (iNOS)PPARG