Target List
Breast Cancer Classification Markers
Luminal A-C Breast Cancers
Esr1 (Erα)Foxa1Gata3Krt8Krt18Slc39a6Tff3Xbp1
HER2-Like Breast Cancers
Erbb2 (Her-2, neu)Grb7
Basal-Like / Triple Negative Breast Cancers
Birc5EgfrKrt5Notch1
Breast Cancer Metastasis to Lung
Id1Mmp2Ptgs2 (Cox2)
Signal Transduction
Steroid Receptor-Mediated Signaling
ArBrca1Ccne1Ctnnb1Esr1 (Erα)Esr2 (Erβ)Igf1Krt19PgrRb1
Hedgehog Signaling
Bcl2Ccnd1Gli1Snai2
Glucocorticoid Signaling
Igfbp3Nme1 (Nm23a)Nr3c1 (GR)
Classical WNT Signaling
ApcCcnd1Ctnnb1Sfrp1
AKT & PI3 Kinase Signaling
Akt1Erbb2 (Her-2, neu)Igf1Igf1rPten
Notch Signaling
Birc5Notch1
MAP Kinase Signaling
Mapk1 (Erk2)Mapk3 (Erk1)Mapk8 (Jnk1)Trp73
Epithelial-to-Mesenchymal Transition (EMT)
Ctnnb1Notch1SrcTgfb1Twist1
Angiogenesis
Cdh13Ctnnb1EgfErbb2 (Her-2, neu)Id1Il6JunNotch1Plau (uPA)PtenSerpine1 (Pai-1)Slit2Thbs1 (TSP-1)Vegfa
Cell Adhesion Molecules
Adam23ApcBcl2Cdh1 (E-cadherin)Cdh13Cdkn2a (p16INK4a)Csf1 (Mcsf)Ctnnb1EgfrErbb2 (Her-2, neu)PtenTgfb1Thbs1 (TSP-1)
Proteases
Adam23Cst6CtsdMmp2Mmp9Plau (uPA)Pycard (Tms1, Asc)
Apoptosis
Akt1ApcBadBcl2Cdh1 (E-cadherin)Cdh13Cdkn1a (p21Cip1, Waf1)Cdkn2a (p16INK4a)Gstp1Igf1Il6JunMuc1 (mucin)Nme1 (Nm23a)RarbSfn (14-3-3σ)Sfrp1Trp53 (p53)Trp73Twist1
Cell Cycle
ApcBcl2Ccna1Ccnd1Ccnd2Ccne1Cdk2Cdkn1a (p21Cip1, Waf1)Cdkn1c (p57Kip2)Cdkn2a (p16INK4a)JunMki67MycPtenRassf1Rb1Sfn (14-3-3σ)Trp53 (p53)
DNA Damage & Repair
ApcAtmBrca1Brca2Ccnd1Cdkn1a (p21Cip1, Waf1)Mapk1 (Erk2)Mgmt (Agt)Mlh1Sfn (14-3-3σ)Trp53 (p53)Trp73
Xenobiotic Transport
Abcb1a (Mdr1)Abcg2 (Bcrp)
Transcription Factors
ArCtnnb1Esr1 (Erα)Esr2 (Erβ)Foxa1Gata3Hic1JunMycNotch1Nr3c1 (GR)PgrPrdm2 (Riz1)RarbRb1Trp53 (p53)Trp73Xbp1