Target List
NFκB Signaling
NFκB Signaling Ligands & Receptors
CD27 (TNFRSF7)CD40 (TNFRSF5)CXCL8 (IL8)EGFR (ERBB1)F2R (PAR1)FASLG (TNFSF6)IL10IL1AIL1BIL1R1LTBRNOD1 (CARD4)TLR1TLR2TLR3TLR4TLR6TLR9TNFTNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF1A (TNFR1)TNFSF10 (TRAIL)TNFSF14
Signaling Downstream of NFκB
BIRC2 (c-IAP1)FADDIRAK1IRAK2IRF1MYD88RIPK1TBK1TICAM1 (TRIF)TICAM2 (TRAM)TNFAIP3TRADDTRAF2TRAF3TRAF6
Cytoplasmic Sequestering / Releasing of NFκB
BCL3CHUK (IKKα)IKBKB (IKKβ)IKBKEIKBKGNFKBIA (IκBα, MAD3)NFKBIB (TRIP9)NFKBIE
Transcription Factors
NFKB1NFKB2RELRELARELB
NFκB Responsive Genes
Immune Response
CCL2 (MCP-1)CCL5 (RANTES)CSF1 (MCSF)CSF2 (GM-CSF)CSF3 (GCSF)CXCL8 (IL8)ICAM1IFNA1IFNGLTA (TNFB)TNF
Apoptosis
AGTBCL2A1 (BFL1)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BIRC3 (c-IAP2)
Other Factors Involved in NFκB Pathway
Kinases
AKT1MAP3K1 (MEKK1)RAF1
Transcription Factors
ATF1EGR1ELK1FOSJUNSTAT1
Other NFκB Signaling Genes
BCL10CARD11CASP1 (ICE)CASP8 (FLICE)CFLAR (CASPER)HMOX1MALT1PSIP1RHOATIMP1