Target List
Channels & Transporters
Water Transporters
AQP1AQP2AQP3AQP4AQP5AQP9
Ion Channels
CFTRKCNJ1MLC1TRPV4
Other Transporters
ABCB1 (MDR1, PGY1)ATP1A1ATP1B1LCN2 (NGAL)SLC14A2SLC2A1SLC38A2SLC5A3SLC6A12SLC6A6SLC9A2SLC9A3
TonEBP / OREBP (NFAT5) Targets
AQP2SLC14A2SLC5A3SLC6A12SLC6A6
Hormones & Receptors
ADMAGTAGTR1AVPEDN1GUCA2AINSNPR1OXT
Molecular Chaperones
CALRCRYABHSP90AA1HSPA1A (HSP70-1A)HSPA4 (HSP70)HSPA4L (OSP94)HSPA5 (GRP78)HSPB1 (HSP27)
DNA Damage & Repair
DDIT3 (GADD153, CHOP)GADD45AGADD45BGADD45GHMOX1MAPK1 (ERK2)TP53 (p53)
Oxidative Stress
CRYABDDIT3 (GADD153, CHOP)DUSP1 (PTPN16)EGFR (ERBB1)FOSHMOX1JUNNOS3 (eNOS)TATTPM4
Regulation of Translation
AKT1CALRHSPB1 (HSP27)MAPK1 (ERK2)ZFP36L1
Mitochondrial Genes
AKT1HSP90AA1HSPA4 (HSP70)JUNMAP3K1 (MEKK1)NOS3 (eNOS)PCK2TP53 (p53)
Cytoskeleton Regulators
CALRCRYABEDN1MAP3K1 (MEKK1)PTK2 (FAK)VIM
Apoptosis
AKT1IL1BMAPK8 (JNK1)NFKBIA (IκBα, MAD3)PAK2SGK1VEGFA
Cell Cycle
AKT1IL1B
Cell Adhesion Molecules
AGTCCN2CD9CXCL8 (IL8)EGFR (ERBB1)IL1BITGB1TNF
Transcription Factors
AKR1B1ATF4DDIT3 (GADD153, CHOP)EGR1EGR3FOSJUNNFAT5PAX2SNAI1 (SNAIL)TP53 (p53)ZFP36L1
Other Osmotic Stress Genes
LTBMAP2K2 (MEK2)ODC1PDIA4PLAT (TPA)SRCTGFA