Target List
Induction of Apoptosis
Death Domain Receptors
CraddFaddTnfTnfrsf10b (Dr5)
DNA Damage & Repair
CideaCidebTrp53 (p53)Trp63 (Tp73l)Trp73
Extracellular Apoptotic Signals
Cflar (Casper)Dapk1
Other Pro-Apoptotic Genes
BadBak1BaxBcl10Bcl2l11BidBnip3Bnip3lBokCasp1 (Ice)Casp12Casp14Casp2Casp3Casp4Casp6Casp8 (Flice)Cd70DffaDffbDiablo (Smac)FasFaslMapk1 (Erk2)Nod1Pycard (Tms1, Asc)Tnfsf10 (Trail)Trp53bp2Traf3
Anti-Apoptotic
Akt1Api5Atf5Bag1Bag3BaxBcl2Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Bcl2l10Bcl2l2Birc3 (cIAP1, cIAP2)Birc5Bnip2Bnip3Bnip3lCd40lgCflar (Casper)Dad1Dapk1FasIgf1rIl10Lhx4Mcl1Naip1 (Birc1)Naip2Nfkb1Nme5Nol3PolbPrdx2TnfTrp63 (Tp73l)Xiap
Regulation of Apoptosis
Negative Regulation of Apoptosis
Bag1Bag3Bcl10Bcl2Bcl2a1a (Bfl-1, A1)Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Bcl2l10Bcl2l2Birc2 (cIAP1, cIAP2)Birc3 (cIAP1, cIAP2)Bnip2Bnip3Bnip3lCasp3Cd40lgCflar (Casper)CideaDapk1DffaFasMcl1Nol3Trp53 (p53)Trp73Xiap
Positive Regulation of Apoptosis
Abl1Akt1Anxa5BadBak1BaxBcl2l11BidBnip3Bnip3lCard10Casp1 (Ice)Casp14Casp2Casp4Casp6Casp8 (Flice)Cd40Cd70CidebCraddFaddFaslGadd45aLtbrNod1Pycard (Tms1, Asc)TnfTnfrsf10b (Dr5)Tnfsf10 (Trail)Tnfsf12 (Apo3l)Trp53 (p53)Trp53bp2Traf1Traf2Traf3
Death Domain Receptors
CraddDapk1FaddNfkb1Ripk1Tnfrsf10b (Dr5)Tnfrsf11b (Opg)Tnfrsf1a (Tnfr1)
Caspases & Regulators
Caspases
Casp1 (Ice)Casp12Casp14Casp2Casp3Casp4Casp6Casp7Casp8 (Flice)Casp9Cflar (Casper)CraddPycard (Tms1, Asc)
Caspase Activation
Aifm1Apaf1BaxBcl2l10Casp1 (Ice)Casp9Nod1Pycard (Tms1, Asc)Tnfrsf10b (Dr5)Trp53 (p53)
Caspase Inhibition
Birc5Xiap