Target List
Upregulated in Immunotoxicity
ABCA1ABCG1ADH1CAHSGAPOA5APOFC9F2 (Thrombin)FABP1GSTA3HPXHRGMARC1NR5A2PON1SERPINA3VPREB1
Downregulated in Immunotoxicity
APOL3APOL4BTNL10BZRAP1CCNB2CDR2CRIM1CTSEGPR17GYPAHMGCS1ISG20KLF1KLF2LYZMKI67SLC7A11SNCATRIM10
Immune Response
AHSGANGC9CCR5CEBPBCTSEHPXF2 (Thrombin)FN1IFI6JCHAINIGSF6ISG20KLF2LAT2LYZPAWRSERPINA3SNCATHBS1 (TSP-1)TLR4VPREB1
Inflammatory Response
AHSGAPOL3CCR5CEBPBF2 (Thrombin)FN1SERPINA3SPP1TLR4
Drug Metabolism
ADH1CALDH8A1BZRAP1CYP3A5GSTA3MARC1MT1FNQO1PON1
Drug Transporters
ABCA1ABCG1SLC25A13SLC31A1SLC7A11
Glucocorticoid Signaling
AK4CEBPBVLDLR
Heat Shock Response
HSPA1BHSPA5 (GRP78)
Oxidative Stress
HPXKLF2MT1FNQO1PON1SLC7A11SNCASRXN1
Unfolded Protein Response
CEBPBCHAC1HSPA1BHSPA5 (GRP78)TM6SF1VLDLR
Cell Cycle
CCNB2CCNG2FBXO32FBXO38KLHL24MKI67
Channels & Transporters
ABCA1ABCG1ATP2B1CHAC1KCNQ1SLC25A13SLC31A1SLC7A11
Cytoskeletal Regulators
ANGGEMIN5GYPAHRGMYH3PAWR
Cytokine & Chemokine Receptors
ACKR3CCR5CRIM1GPR17TLR4
Extracellular Matrix (ECM) & Cell Adhesion Molecules
FEZ1FN1GPNMBHRGSERPINA3SPP1THBS1 (TSP-1)
G-Protein Coupled Receptor Signaling
ARRDC3CCR5ACKR3GPR17GPR18
Lipoprotein Signaling & Cholesterol Metabolism
ABCA1ABCG1ALDH8A1APOA5APOFAPOL3APOL4HMGCS1VLDLRVPREB1
Transcription Factors
ATF3CEBPBID1ID2KLF1KLF2NR5A2PAWRTRIM10ZDHHC14
Other Immunotoxicity Genes
BTNL10C7orf50CDR2FABP1METAP2NEU4PSD3SNX25VMP1