Target List
Senescence Pathway
ATMBMI1CCND1CCNE1CDK2CDK4CDK6CDKN1ACDKN2ACDKN2DCHEK1CHEK2E2F1E2F3ETS1ETS2MDM2RB1RBL2TP53TWIST1
Senescence Initiators
p53 Signaling
ABL1
p53 / pRb Signaling & the Cell Cycle
AKT1ALDH1A3CCNA2CCNB1CDC25CCDKN1CCDKN2BCDKN2CCITED2CREG1GSK3BID1IGF1RIGFBP3ING1MAP2K6MAPK14MORC3MYCPCNAPIK3CAPLAURBL1SERPINB2SERPINE1SIRT1SPARCTGFB1
Interferon Signaling
ALDH1A3CDKN1ACDKN1BEGR1IFNGIGFBP3IGFBP7IRF3IRF5IRF7NFKB1RB1SERPINB2
Insulin Growth Factor (IGF) Related
IGF1IGF1RIGFBP3IGFBP5IGFBP7
MAP Kinase Signaling
HRASMAP2K1MAP2K3MAP2K6MAPK14
Oxidative Stress
ALDH1A3HRASMAPK14NOX4PRKCDSOD1SOD2
DNA Damage & Repair
ATMGADD45ANBNPCNATERF2TERTTP53BP1
Senescence Responses
p53 Effectors
ALDH1A3E2F1HRASIGFBP3MYC
p21 Effectors
CALR
p16 Effectors
TBX2TBX3
Cytoskeleton Regulators
AKT1FN1HRASPIK3CAPLAUSERPINE1SPARCTHBS1VIM
Cell Adhesion Molecules
CD44COL1A1COL3A1TGFB1TGFB1I1THBS1
Other Senescence Response Genes
GLB1PTEN