Target List
mTOR Complexes
mTORC1 Complex
MLST8MTORRPTOR
mTORC2 Complex
MAPKAP1MLST8MTORRICTOR
mTOR Upstream Regulators
mTORC1 Positive Regulation
AKT1AKT2AKT3HRASIGF1IKBKBINSINSRIRS1MAPK1MAPK3PDPK1PIK3C3PIK3CAPIK3CBPIK3CDPIK3CGPLD1PLD2RHEBRPS6KA1RPS6KA2RPS6KA5RRAGARRAGBRRAGCRRAGDTELO2
mTORC2 Positive Regulation
AKT1AKT2AKT3MAPK1MAPK3PDPK1PIK3C3PIK3CAPIK3CBPIK3CDPIK3CGRHEBRPS6KA1RPS6KA2RPS6KA5
mTORC1 Negative Regulation
AKT1S1CAB39CAB39LDDIT4DDIT4LDEPTORFKBP1AFKBP8IGFBP3PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3PTENSTK11STRADBTP53TSC1TSC2YWHAQ
mTORC2 Negative Regulation
CAB39CAB39LDDIT4DDIT4LDEPTORPRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3STK11STRADBTSC1TSC2
mTOR Downstream Effectors
mTORC1 Positive Regulation
CHUKEIF4BEIF4EHIF1AIKBKBRPS6RPS6KB1RPS6KB2TP53VEGFAVEGFBVEGFC
mTORC2 Positive Regulation
AKT1CDC42GSK3BHSPA4ILKMYO1CPRKCAPRKCBPRKCEPRKCGRHOARPS6KB1SGK1
mTORC1 Negative Regulation
EIF4EBP1EIF4EBP2PPP2CAPPP2R2BPTPATP53ULK1ULK2
Cellular Processes Regulated by mTOR Signaling
Amino Acid Response
PIK3C3RRAGARRAGBRRAGCRRAGD
Angiogenesis
CHUKDDIT4DDIT4LHIF1AIKBKBVEGFAVEGFBVEGFC
Autophagy
PIK3C3ULK1ULK2
Cytoskeletal Organization
CDC42PRKCAPRKCBPRKCEPRKCGRHOA
Growth Factor Response
HRASIGF1IGFBP3MAPK1MAPK3RPS6KA1RPS6KA2RPS6KA5
Energy Stress
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3
Insulin Signaling
AKT1AKT2AKT3INSINSRIRS1PDPK1PIK3CAPIK3CBPIK3CDPIK3CGTP53
Lipid Metabolism
PLD1PLD2
Translation
EIF4BEIF4EEIF4EBP1EIF4EBP2PPP2CAPPP2R2BPTPARPS6RPS6KA1RPS6KA2RPS6KA5RPS6KB1RPS6KB2