Target List
Up-Regulated in Hepatocellular Carcinoma
Bcl2Birc5Cav1Ccnd1CflarFzd7Igf2Irs1Lef1MetNfkb1Pin1Ptk2Rac1RhoaSmad7Stat3Tcf4TgfaTgfb1Tnfsf10Xiap
Down-Regulated in Hepatocellular Carcinoma
BaxBidCasp8Cdkn1aCdkn2aDlc1FaddFasHhipIgfbp1Igfbp3Itgb1PtenRb1Smad4Socs1Socs3Tgfbr2Tnfrsf10b
Signal Transduction
Classical WNT Signaling
Ccnd1Cdkn2aCtnnb1Fzd7Lef1MtdhPin1Rb1Sfrp2Tcf4
TGFβ Signaling
Smad4Smad7Tgfb1Tgfbr2
AKT & PI3 Kinase Signaling
Akt1Irs1Pten
IGF / IGFR Signaling
Igf2Igfbp1Igfbp3Irs1
Hippo Signaling
Yap1
RAS / RAF / MAP Kinase Signaling
Cdkn1aCdkn2aDlc1HrasNrasRac1Rassf1Rb1RhoaTp53
EGFR Signaling
Adam17Cdh13EgfEgfrTgfaTgfb1
MET / HGF Signaling
HgfMet
G-Protein Signaling
Cdh13Cdkn1aCdkn2aDab2ipDlc1HrasNrasRac1Rassf1Rb1RelnRhoaTp53
Epithelial-to-Mesenchymal Transition (EMT)
Ctnnb1HgfLef1Smad4Smad7Tgfb1
Cell Cycle
Birc5Ccnd1Ccnd2Cdkn1aCdkn1bCdkn2aE2f1Ep300Gadd45bIgf2MycPtenRassf1Runx3
Apoptosis
BaxBcl2Bcl2l1Bcl2l1Bcl2l1BidBirc2Birc5Casp8Cav1CflarDlc1E2f1Ep300FaddFasGadd45bGstp1Msh2PycardRunx3Socs3TertTnfrsf10bTnfsf10Wt1
Immune & Inflammatory Responses
Ccl3Ccl5Cxcr4Nfkb1Ptgs2Rac1Tgfb1Tlr4
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Adam17Akt1Cdh1Cdh13CflarDlc1EgfrEp300HgfItgb1Lef1OpcmlPtenPycardRac1RelnRhoaSmad7Socs1Socs3Tgfb1
Angiogenesis
Angpt2Casp8Cav1Cdh13Ctnnb1EgfFlt1KdrPdgfraPtenPtk2Tgfbr2Vegfa
DNA Damage & Repair
Ccnd1Cdkn1aMsh2Msh3Tp53Xiap