Target List
Caspases & Regulators
Caspases
CARD17CARD18CASP1CASP10CASP14CASP2CASP3CASP4CASP5CASP6CASP7CASP8CASP9CFLARCRADDMALT1PYCARDCOP1
Caspase Activation
AIFM3APAF1BAXBBC3BCL2L10BCL2L13CASP1CASP8AP2CASP9COL4A3CYCSDIABLOEIF2AK3F2F2RFOXL2HIP1HSPE1IFNB1IFT57LCKMAP3K5MOAP1MTCH1MYCNLRC4NLRP1NLRP12NLRP2NLRP3NOD1PMAIP1PYCARDSTAT1TNFRSF10ATNFRSF10BTNFSF15TP53TPD52L1VCP
Caspase Inhibition
BIRC5CD27DHCR24IFI6LAMTOR5SFNTNFAIP8TNFSF14TRIAP1XIAP
Anti-Apoptotic
Positive Regulation of Anti-Apoptosis
BCL2L1BCL2L1BCL2L1BRECD28ERC1MAPK8IP2OPA1PRKAA1RASA1
Negative Regulation of Anti-Apoptosis
PIK3R2RTN4TNFAIP8
Other Anti-Apoptotic Genes
AATFAKT1ALOX12ANXA1ANXA4API5ATF5AVENAZU1BAG1BAG3BAG4BCL2BCL2A1BCL2L1BCL2L1BCL2L1BCL2L10BCL2L2BDNFBECN1BFARBIRC2BIRC3BIRC5BIRC6BIRC7BIRC8BNIP1BNIP2BNIP3BRAFCASP2CBX4CCL2CD27CD40LGCEBPBCFDP1CFL1CFLARCRYAACRYABDAD1DDAH2DHCR24EEF1A2FAIMFAIM2FASFOXO1GDNFGFRALGLO1GSTP1HDAC1HDAC3HIPK3HMGB1HSP90B1HSPA1BHSPA9HSPB1HTATIP2HTTIER3IFI6IGF1RIL10IL1AIL2IL31RALAMTOR5MALT1MCL1MKL1MPOTESMINMYBL2MYO18ANAIPNFKB1NME5NOL3NOTCH2NPM1NRG2NTF3PAK7PAX7PEA15PIK3CAPIM2POGKPOLBPRDX2PRKCZPRLRPROK2PSEN1RELARNF7SEMA4DSERPINB2SERPINB9SFRP1SH3GLB1SNCASOCS2SOCS3SONSPHK1SPP1STAMBPTAX1BP1TBX3TGFB1TIAF1TMX1TNFTNFAIP3TNFAIP8TNFRSF10DTNFRSF18TNFRSF6BTNFSF18TPT1TRIAP1TSC22D3VEGFAVHLXIAPYWHAZZC3HC1
Induction of Apoptosis
Induction of Apoptosis by Death Domain Receptors
BIDCRADDDAXXDEDD2FADDIL18TNFTNFRSF10B
Induction of Apoptosis by DNA Damage
ABL1AIFM1BCL3BRCA1CHEK2CIDEACIDEBDYRK2IFI16MBD4MSH6PCBP4PMLSFNTP53TP73
Induction of Apoptosis by Oxidative Stress
GPX1PRODHRNF7TP53I3
Induction of Apoptosis by Extracellular Signals
ADORA1BTKCASP8AP2CD28CD38CD5CFLARDAPDAP3DAPK1DPF2FASTKMAP3K5NDUFA13PDCD6PRKCARIPK3SPNTIMP3TNFRSF25
Induction of Apoptosis by Intracellular Signals
CDKN1ACUL1CUL2CUL3CUL4ACUL5HIPK2MYCSART1
Other Pro-Apoptotic Genes
ACVR1BAIFM2AIFM3ALOX15BAPOEBADBAK1BAXBBC3BCL10BCL2L11BCL2L13BCLAF1BIKBNIP1BNIP3BNIP3LBOKCASP10CASP3CASP4CASP6CD2CD27CD70CEBPBCIDECCOL4A3DAPK2DAPK3DCCDDX20DEDDDIABLOEI24ERCC2ERCC3ERN1ERN2FASFASLGFEM1BFOXL2FOXO3HRKHTATIP2IFNA2IFNB1IFNGIKBIPIKBKGIL19INHAINHBAJMYLALBALCKLTAMALMAP3K10MAPK1MX1NDUFS3NGFRNLRP1NLRP3NME3NOTCH2NOX5NUDT2NUPR1PDCD5PLAGL1PLAGL2PLEKHF1PLGPMAIP1PPP1R13BPPP2CAPPP2R1APPP2R1BPRKCEPRKRAPRUNE2PTENPTHPYCARDRPS3ARUNX3S100BSAP30BPSERINC3SIPA1SMNDC1SSTSSTR3STK17ASTK17BTBX5TIA1TIAL1TLR2TNFRSF10ATNFRSF19TNFRSF9TNFSF10TNFSF14TNFSF8TP53BP2TP63TPD52L1TRADDTRAF3TRAIPUNC13BUTP11LZNF443
TNF Domain Proteins
EDAFASLGLTALTBTNFTNFSF10TNFSF14TNFSF15TNFSF8
TNFR Domain Proteins
CD27CD40FASLTBRNGFRTNFRSF10ATNFRSF10BTNFRSF10DTNFRSF18TNFRSF19TNFRSF1ATNFRSF1BTNFRSF21TNFRSF25TNFRSF6BTNFRSF8TNFRSF9
BCL2 & BAG Domain Proteins
BAG1BAG3BAG4BAXBCL2BCL2A1BCL2L1BCL2L1BCL2L1BCL2L10BCL2L13BCL2L2MCL1
BIR Domain Proteins
BIRC2BIRC3BIRC5BIRC6BIRC7BIRC8NAIPXIAP
CARD Domain Proteins
APAF1BCL10BIRC2BIRC3CARD10CARD11CARD14CARD17CARD18CARD6CARD9CASP1CASP2CASP4CASP5CASP9CRADDNLRP1NOD1NOD2NOL3PYCARDCOP1RIPK2
Death Domain Receptors
CRADDDAPK1EDARFADDMALT1NFKB1NFKB2NGFRPIDD1RIPK1TNFRSF10ATNFRSF10BTNFRSF1ATNFRSF21TNFRSF25TRADD
TRAF Domain Proteins
TRAF2TRAF3TRAF5TRAF7
Other Apoptosis Regulators
BCL6CEBPGDBPDDIT3GRM4LGALS1MADDMAPK8NKX3-2POU4F1PROP1RARGSTAT5ASTAT5BTBK1TDGF1TRAF6MAP3K20