Target List
mTOR Complexes
mTORC1 Complex
MLST8MTORRPTOR
mTORC2 Complex
MLST8MTORRICTOR
mTOR Upstream Regulators
mTORC1 Positive Regulation
AKT1AKT2AKT3IGF1IKBKBINSINSRIRS1KRASMAPK1MAPK1MAPK3MAPK3NRASPDPK1PIK3C3PIK3CALOC100622663PIK3CDPIK3CGPIK3R2PLD1PLD2RHEBRPS6KA1RPS6KA2RPS6KA4LOC100152046RRAGARRAGCRRAGDTELO2
mTORC2 Positive Regulation
AKT1AKT2AKT3MAPK1MAPK1MAPK3MAPK3PDPK1PIK3C3PIK3CALOC100622663PIK3CDPIK3CGPIK3R2RHEBRPS6KA1RPS6KA2RPS6KA4LOC100152046
mTORC1 Negative Regulation
AKT1S1CAB39CAB39LDDIT4DDIT4LDEPTORFKBP1AFKBP8IGFBP3PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1LOC100738310PTENSTK11STRADBTP53TSC1TSC2YWHAQ
mTORC2 Negative Regulation
CAB39CAB39LDDIT4DDIT4LDEPTORPRKAA1PRKAA2PRKAB1PRKAB2PRKAG1LOC100738310STK11STRADBTSC1TSC2
mTOR Downstream Effectors
mTORC1 Positive Regulation
CHUKEIF4EHIF1AIKBKBRPS6RPS6KB1RPS6KB2TP53VEGFAVEGFBVEGFC
mTORC2 Positive Regulation
AKT1CDC42GSK3BHSPA4ILKMYO1CPRKCAPRKCBPRKCEPRKCGRHOARPS6KB1SGK1
mTORC1 Negative Regulation
EIF4EBP1EIF4EBP2PPP2CAPPP2R2BPPP2R4TP53ULK1ULK2
Cellular Processes
Amino Acid Response
PIK3C3RRAGARRAGCRRAGD
Angiogenesis
CHUKDDIT4DDIT4LHIF1AIKBKBVEGFAVEGFBVEGFC
Autophagy
PIK3C3ULK1ULK2
Cytoskeletal Organization
CDC42PRKCAPRKCBPRKCEPRKCGRHOA
Growth Factor Response
BRAFIGF1IGFBP3KRASMAPK1MAPK1MAPK3MAPK3NRASRPS6KA1RPS6KA2RPS6KA4LOC100152046
Energy Stress
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1LOC100738310
Insulin Signaling
AKT1AKT2AKT3INSINSRIRS1PDPK1PIK3CALOC100622663PIK3CDPIK3CGPIK3R2TP53
Lipid Metabolism
BRAFPLD1PLD2
Translation
EIF4EEIF4EBP1EIF4EBP2PPP2CAPPP2R2BPPP2R4RPS6RPS6KA1RPS6KA2RPS6KA4LOC100152046RPS6KB1RPS6KB2