Target List
Breast Cancer Classification Markers
Luminal A-C Breast Cancers
ESR1 (ERα)FOXA1GATA3KRT8KRT18SLC39A6TFF3XBP1
HER2-Like Breast Cancers
ERBB2 (HER-2, NEU)GRB7
Basal-Like / Triple Negative Breast Cancers
BIRC5EGFR (ERBB1)KRT5NOTCH1
Breast Cancer Metastasis to Lung
ID1MMP2PTGS2 (COX2)
Signal Transduction
Steroid Receptor-Mediated Signaling
ARBRCA1CCNE1CTNNB1ESR1 (ERα)ESR2 (ERβ)IGF1KRT19PGRRB1
Hedgehog Signaling
BCL2CCND1GLI1SNAI2
Glucocorticoid Signaling
IGFBP3NME1 (NM23)NR3C1 (GRL)
Classical WNT Signaling
APCCCND1CTNNB1SFRP1
AKT & PI3 Kinase Signaling
AKT1ERBB2 (HER-2, NEU)IGF1IGF1RPTEN
Notch Signaling
BIRC5NOTCH1
MAP Kinase Signaling
MAPK1 (ERK2)MAPK3 (ERK1)MAPK8 (JNK1)TP73
Epithelial-to-Mesenchymal Transition (EMT)
CTNNB1NOTCH1SRCTGFB1TWIST1
Angiogenesis
CDH13CTNNB1EGFERBB2 (HER-2, NEU)ID1IL6JUNNOTCH1PLAU (UPA)PTENSERPINE1 (PAI-1)SLIT2THBS1 (TSP-1)VEGFA
Cell Adhesion Molecules
ADAM23APCBCL2CDH1 (E-Cadherin)CDH13CDKN2A (P16INK4A)CSF1 (MCSF)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)PTENTGFB1THBS1 (TSP-1)
Proteases
ADAM23CST6CTSDMMP2MMP9PLAU (UPA)PYCARD (TMS1, ASC)
Apoptosis
AKT1APCBADBCL2CDH1 (E-Cadherin)CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)GSTP1IGF1IL6JUNMUC1 (mucin)NME1 (NM23)RARBSFN (14-3-3σ, YWHAS)SFRP1TP53 (p53)TP73TWIST1
Cell Cycle
APCBCL2CCNA1CCND1CCND2CCNE1CDK2CDKN1A (p21CIP1, WAF1)CDKN1C (p57Kip2)CDKN2A (P16INK4A)JUNMKI67MYCPTENRASSF1RB1SFN (14-3-3σ, YWHAS)TP53 (p53)
DNA Damage & Repair
APCATMBRCA1BRCA2CCND1CDKN1A (p21CIP1, WAF1)MAPK1 (ERK2)MGMT (AGT)MLH1SFN (14-3-3σ, YWHAS)TP53 (p53)TP73
Xenobiotic Transport
ABCB1 (MDR1, PGY1)ABCG2 (BCRP)
Transcription Factors
ARCTNNB1ESR1 (ERα)ESR2 (ERβ)FOXA1GATA3HIC1JUNMYCNOTCH1NR3C1 (GRL)PGRPRDM2 (RIZ1)RARBRB1TP53 (p53)TP73XBP1