Target List
Immune & Inflammatory Responses
Immunostimulatory Factors
IFNGIL2IL12AIL12BIL15TNF
Immunosuppressive Factors
CD274 (PD-L1)CD274 (PD-L1)CSF2 (GM-CSF)CTLA4CXCL12 (SDF1)CXCL5 (ENA-78, LIX)IDO1 (IDO)IDO1 (IDO)IL10IL13IL4CXCL8 (IL8)MIFNOS2 (iNOS)PDCD1 (PD1)PDCD1 (PD1)PTGS2 (COX2)TGFB1VEGFA
Pro-Inflammatory Genes
CCL2 (MCP-1)CCL20 (MIP-3A)IFNGIL1AIL1BIL2IL6IL12AIL12BIL17AIL23APTGS2 (COX2)TLR4TNFVEGFA
Anti-Inflammatory Genes
IL4IL10IL13TGFB1
Enzymatic Modulators of Inflammation & Immunity
AICDA (AID)AICDA (AID)GZMAGZMBIDO1 (IDO)IDO1 (IDO)NOS2 (iNOS)PTGS2 (COX2)
Antigen Presentation
HLA-AHLA-BHLA-CMICAMICB
Chemokines
CCL2 (MCP-1)CCL4 (MIP-1B)CCL5 (RANTES)CCL18 (PARC)CCL20 (MIP-3A)CCL21 (MIP-2)CCL22 (MDC)CCL28CXCL1 (GRO1, GROa, SCYB1)CXCL2 (GRO2, GROb, SCYB2)CXCL5 (ENA-78, LIX)CXCL9 (MIG)CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL12 (SDF1)
Chemokine Receptors
ACKR3CCR1CCR2CCR4CCR7CCR9CCR10CXCR1CXCR2CXCR3CXCR4CXCR5
Interleukins
IL1AIL1BIL2IL4IL6CXCL8 (IL8)IL10IL12AIL12BIL13IL15IL17AIL23A
Other Cytokines
KITLG (SCF)KITLG (SCF)MIFSPP1TNFTNFSF10 (TRAIL)
Growth Factors & Receptors
CSF1 (MCSF)CSF2 (GM-CSF)CSF3 (GCSF)EGFEGFR (ERBB1)IGF1TGFB1VEGFA
Signal Transduction
Interferon Signaling
GBP1IFNGIL6IRF1
Interferon-Responsive Genes
CCL2 (MCP-1)CCL5 (RANTES)CXCL9 (MIG)CXCL10 (INP10)GBP1IRF1MYD88STAT1TLR3TNFSF10 (TRAIL)
NFκB Targets
BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CCL2 (MCP-1)CCL5 (RANTES)CSF1 (MCSF)CSF2 (GM-CSF)CSF3 (GCSF)IFNGCXCL8 (IL8)TNF
STAT Targets
CCL2 (MCP-1)CCL4 (MIP-1B)CCL5 (RANTES)CSF1 (MCSF)CSF2 (GM-CSF)CSF3 (GCSF)CXCL9 (MIG)CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL12 (SDF1)IL1BIL6CXCL8 (IL8)IL10IL17AIL23AMYC
Toll-Like Receptor Signaling
TLR2TLR3TLR4MYD88
Transcription Factors
FOXP3HIF1AIRF1MYCNFKB1STAT1STAT3TP53 (p53)
Apoptosis
Pro-Apoptotic
FASLG (TNFSF6)TNFTNFSF10 (TRAIL)TP53 (p53)
Anti-Apoptotic
BCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)MYCSTAT3