Target List
Up-Regulated in Hepatocellular Carcinoma
Bcl2Birc5Cav1Ccnd1Cflar (Casper)Fzd7Igf2Irs1Lef1MetNfkb1Pin1Ptk2 (Fak)Rac1RhoaSmad7Stat3Tcf4TgfaTgfb1Tnfsf10 (Trail)Xiap
Down-Regulated in Hepatocellular Carcinoma
BaxBidCasp8 (Flice)Cdkn1a (Cip1, Waf1)Cdkn2a (INK4A, p16, p19ARF)Dlc1FaddFasHhipIgfbp1Igfbp3Itgb1PtenRb1Smad4Socs1Socs3Tgfbr2Tnfrsf10b (QuantiNova Symbol: AABR07018323.1)
Signal Transduction
Classical WNT Signaling
Ccnd1Cdkn2a (INK4A, p16, p19ARF)Ctnnb1Fzd7Lef1MtdhPin1Rb1Sfrp2Tcf4
TGFβ Signaling
Smad4Smad7Tgfb1Tgfbr2
AKT & PI3 Kinase Signaling
Akt1Irs1Pten
IGF / IGFR Signaling
Igf2Igfbp1Igfbp3Irs1
Hippo Signaling
Yap1
RAS / RAF / MAP Kinase Signaling
Cdkn1a (Cip1, Waf1)Cdkn2a (INK4A, p16, p19ARF)Dlc1HrasNrasRac1Rassf1Rb1RhoaTp53 (p53)
EGFR Signaling
Adam17 (Cd156b)Cdh13EgfEgfrTgfaTgfb1
MET / HGF Signaling
HgfMet
G-Protein Signaling
Cdh13Cdkn1a (Cip1, Waf1)Cdkn2a (INK4A, p16, p19ARF)Dab2ipDlc1HrasNrasRac1Rassf1Rb1RelnRhoaTp53 (p53)
Epithelial-to-Mesenchymal Transition (EMT)
Ctnnb1HgfLef1Smad4Smad7Tgfb1
Cell Cycle
Birc5Ccnd1Ccnd2Cdkn1a (Cip1, Waf1)Cdkn1b (P27KIP1)Cdkn2a (INK4A, p16, p19ARF)E2f1Ep300 (QuantiNova Symbol: AABR07058539.1)Gadd45bIgf2MycPtenRassf1Runx3
Apoptosis
BaxBcl2Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)BidBirc2 (c-IAP2)Birc5Casp8 (Flice)Cav1Cflar (Casper)Dlc1E2f1Ep300 (QuantiNova Symbol: AABR07058539.1)FaddFasGadd45bGstp1Msh2Pycard (Tms1, Asc)Runx3Socs3TertTnfrsf10b (QuantiNova Symbol: AABR07018323.1)Tnfsf10 (Trail)Wt1
Immune & Inflammatory Responses
Ccl3 (Mip-1a)Ccl5 (Rantes)Cxcr4Nfkb1Ptgs2 (Cox2)Rac1Tgfb1Tlr4
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Adam17 (Cd156b)Akt1Cdh1 (E-cadherin)Cdh13Cflar (Casper)Dlc1EgfrEp300 (QuantiNova Symbol: AABR07058539.1)HgfItgb1Lef1OpcmlPtenPycard (Tms1, Asc)Rac1RelnRhoaSmad7Socs1Socs3Tgfb1
Angiogenesis
Angpt2Casp8 (Flice)Cav1Cdh13Ctnnb1EgfFlt1 (Vegfr1)Kdr (Vegfr3)PdgfraPtenPtk2 (Fak)Tgfbr2Vegfa
DNA Damage & Repair
Ccnd1Cdkn1a (Cip1, Waf1)Msh2Msh3Tp53 (p53)Xiap