Target List
mTOR Complexes
mTORC1 Complex
MLST8 (GBL)MTORRPTOR
mTORC2 Complex
MLST8 (GBL)MTORRICTOR
mTOR Upstream Regulators
mTORC1 Positive Regulation
AKT1AKT2AKT3IGF1IKBKBINSINSRIRS1KRASMAPK1 (ERK2)MAPK1 (ERK2)MAPK3 (ERK1)MAPK3 (ERK1)NRASPDPK1PIK3C3 (VPS34)PIK3CA (p110-alpha)LOC100622663 (PIK3CB)PIK3CDPIK3CGPIK3R2 (p85-BETA)PLD1PLD2RHEBRPS6KA1RPS6KA2RPS6KA4LOC100152046RRAGARRAGCRRAGDTELO2
mTORC2 Positive Regulation
AKT1AKT2AKT3MAPK1 (ERK2)MAPK1 (ERK2)MAPK3 (ERK1)MAPK3 (ERK1)PDPK1PIK3C3 (VPS34)PIK3CA (p110-alpha)LOC100622663 (PIK3CB)PIK3CDPIK3CGPIK3R2 (p85-BETA)RHEBRPS6KA1RPS6KA2RPS6KA4LOC100152046
mTORC1 Negative Regulation
AKT1S1CAB39CAB39LDDIT4 (REDD1)DDIT4L (REDD2)DEPTOR (DEPDC6)FKBP1AFKBP8IGFBP3PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1LOC100738310PTENSTK11 (LKB1)STRADBTP53 (p53)TSC1TSC2YWHAQ (14-3-3θ)
mTORC2 Negative Regulation
CAB39CAB39LDDIT4 (REDD1)DDIT4L (REDD2)DEPTOR (DEPDC6)PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1LOC100738310STK11 (LKB1)STRADBTSC1TSC2
mTOR Downstream Effectors
mTORC1 Positive Regulation
CHUK (IKKα)EIF4EHIF1AIKBKBRPS6RPS6KB1RPS6KB2TP53 (p53)VEGFAVEGFBVEGFC (VEGFC)
mTORC2 Positive Regulation
AKT1CDC42GSK3BHSPA4 (HSP70)ILKMYO1CPRKCAPRKCBPRKCEPRKCGRHOARPS6KB1SGK1
mTORC1 Negative Regulation
EIF4EBP1 (4E-BP1)EIF4EBP2PPP2CAPPP2R2BPPP2R4TP53 (p53)ULK1ULK2
Cellular Processes
Amino Acid Response
PIK3C3 (VPS34)RRAGARRAGCRRAGD
Angiogenesis
CHUK (IKKα)DDIT4 (REDD1)DDIT4L (REDD2)HIF1AIKBKBVEGFAVEGFBVEGFC (VEGFC)
Autophagy
PIK3C3 (VPS34)ULK1ULK2
Cytoskeletal Organization
CDC42PRKCAPRKCBPRKCEPRKCGRHOA
Growth Factor Response
BRAFIGF1IGFBP3KRASMAPK1 (ERK2)MAPK1 (ERK2)MAPK3 (ERK1)MAPK3 (ERK1)NRASRPS6KA1RPS6KA2RPS6KA4LOC100152046
Energy Stress
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1LOC100738310
Insulin Signaling
AKT1AKT2AKT3INSINSRIRS1PDPK1PIK3CA (p110-alpha)LOC100622663 (PIK3CB)PIK3CDPIK3CGPIK3R2 (p85-BETA)TP53 (p53)
Lipid Metabolism
BRAFPLD1PLD2
Translation
EIF4EEIF4EBP1 (4E-BP1)EIF4EBP2PPP2CAPPP2R2BPPP2R4RPS6RPS6KA1RPS6KA2RPS6KA4LOC100152046RPS6KB1RPS6KB2