Target List
Autophagy Machinery Components
Autophagic Vacuole Formation
AMBRA1 (NYW1)ATG12ATG16L1ATG4AATG4BATG4CATG4DATG5ATG9AATG9BBECN1GABARAPGABARAPL1GABARAPL2IRGMMAP1LC3AMAP1LC3BRGS19ULK1WIPI1
Vacuole Targeting
ATG4AATG4BATG4CATG4DGABARAP
Protein Transport
ATG10ATG16L1ATG16L2ATG3ATG4AATG4BATG4CATG4DATG7ATG9AGABARAPGABARAPL2RAB24
Autophagosome-Lysosome Linkage
DRAM1GABARAPLAMP1NPC1
Ubiquitination
ATG3ATG7HDAC6
Proteases
ATG4AATG4BATG4CATG4D
Regulation of Autophagy
Co-Regulators of Autophagy & Apoptosis
AKT1APPATG12ATG5BADBAK1BAXBCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BECN1BIDBNIP3CASP3CASP8 (FLICE)CDKN1B (P27KIP1)CDKN2A (P16INK4A)CLN3CTSBCXCR4DAPK1DRAM1EIF2AK3FADDFASHDAC1HTTIFNGIGF1INSMAPK8 (JNK1)MTORNFKB1PIK3CGPRKAA1 (AMPK)PTENSNCASQSTM1TGFB1TGM2TNFTNFSF10 (TRAIL)TP53 (p53)
Co-Regulators of Autophagy & the Cell Cycle
BAXCDKN1B (P27KIP1)CDKN2A (P16INK4A)IFNGPTENRB1TGFB1TP53 (p53)
Autophagy Induction by Intracellular Pathogens
EIF2AK3IFNGLAMP1
Autophagy in Response to Other Intracellular Signals
CTSDCTSSDRAM2EIF4G1ESR1 (ERα)GAAHGSMAPK14 (p38ALPHA)PIK3C3 (VPS34)PIK3R4RPS6KB1TMEM74ULK2UVRAG
Chaperone-Mediated Autophagy
HSP90AA1HSPA8