Target List
Up-Regulated During Epithelial-to-Mesenchymal Transition
AHNAKBMP1CALD1CAMK2N1CDH2 (N-Cadherin)COL1A2COL3A1COL5A2FN1FOXC2GNG11GSCIGFBP4ITGA5ITGAVMMP2MMP3MMP9MSNSERPINE1 (PAI-1)SNAI1 (SNAIL)SNAI2SNAI3SOX10SPARCSTEAP1TCF4TIMP1TMEFF1TMEM132ATWIST1VCANVIMVPS13AWNT5AWNT5B
Down-Regulated During Epithelial-to-Mesenchymal Transition
CAV2CDH1 (E-Cadherin)DSPFGFBP1IL1RNKRT19MST1R (RON)NUDT13OCLNDESI1RGS2SPP1TFPI2TSPAN13
Differentiation & Development
AKT1BMP1BMP2BMP7COL3A1COL5A2CTNNB1DSPERBB3F11RFOXC2FZD7GSCJAG1KRT14MST1R (RON)NODALNOTCH1PTP4A1SMAD2 (MADH2)SNAI1 (SNAIL)SNAI2SOX10TGFB2TGFB3TMEFF1TWIST1VCANWNT11WNT5AWNT5B
Cell Morphogenesis
CTNNB1FOXC2JAG1RAC1SMAD2 (MADH2)SNAI1 (SNAIL)SOX10TGFB1TGFB2TGFB3TWIST1WNT11WNT5A
Cell Growth & Proliferation
AKT1BMP1BMP7CAV2CTNNB1EGFR (ERBB1)ERBB3FGFBP1FOXC2IGFBP4ILKJAG1MST1R (RON)NODALPDGFRBTGFB1TGFB2TGFB3TIMP1VCANZEB1
Cell Migration & Motility
CALD1CAV2EGFR (ERBB1)FN1ITGB1JAG1MSNMST1R (RON)NODALPDGFRBRAC1STAT3TGFB1VIM
Cytoskeleton Regulators
CAV2KRT7MAP1BPLEK2RAC1VIM
Extracellular Matrix (ECM) & Cell Adhesion Molecules
BMP1BMP7CDH1 (E-Cadherin)CDH2 (N-Cadherin)COL1A2COL3A1COL5A2CTNNB1DSC2EGFR (ERBB1)ERBB3F11RFN1FOXC2ILKITGA5ITGAVITGB1MMP2MMP3MMP9PTK2 (FAK)RAC1SERPINE1 (PAI-1)SPP1TGFB1TGFB2TIMP1VCAN
Signal Transduction
Estrogen Receptor Signaling
CAV2ESR1 (ERα)KRT19TGFB3
G-Protein Coupled Receptor Signaling
AKT1FZD7GNG11RAC1RGS2
Integrin-Mediated Signaling
COL3A1ILKITGA5ITGAVITGB1PTK2 (FAK)
Notch Signaling
FOXC2JAG1NOTCH1
Receptor Tyrosine Kinase Signaling
EGFR (ERBB1)ERBB3PDGFRBRGS2SPARC
TGFβ / BMP Signaling
BMP1BMP2BMP7COL3A1SMAD2 (MADH2)TGFB1TGFB2TGFB3
WNT Signaling
CTNNB1FZD7GSK3BWNT11WNT5AWNT5B
Transcription Factors
CTNNB1ESR1 (ERα)FOXC2GSCNOTCH1GEMIN2SMAD2 (MADH2)SNAI2SNAI3SOX10STAT3TCF3TCF4TWIST1ZEB1ZEB2