Target List
Insulin Signaling
AKT1FOXA2 (HNF3B)FOXO1GSK3BIGF1IGFBP1INSRIRS1MAPK1 (ERK2)MAPK8 (JNK1)MTORPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PKLRPPARGC1A (PGC-1α)PRKAA1 (AMPK)PTPN1 (PTP1B)SLC2A4 (GLUT4)SOCS3SREBF1
Adipokine Signaling
ADIPOR1ADIPOR2AKT1CD36IRS1LEPRMAPK8 (JNK1)MTORNFKB1PPARAPPARGC1A (PGC-1α)PRKAA1 (AMPK)RXRASERPINE1 (PAI-1)SLC2A1SLC2A4 (GLUT4)SOCS3STAT3TNF
Non-Insulin Dependent Diabetes Mellitus
GCKINSRIRS1MAPK1 (ERK2)MAPK8 (JNK1)MTORPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PKLRPNPLA3SLC2A2SLC2A4 (GLUT4)SOCS3TNFXBP1
Metabolic Pathways
Carbohydrate Metabolism
ACLYG6PCG6PDGCKGSK3BMLXIPLPCK2PDK4PKLRRBP4
Beta-Oxidation
ACADLACOX1AKT1CPT1ACPT2FABP1IRS1MTORPPARA
Cholesterol Metabolism & Transport
ABCA1APOA1APOBAPOC3APOECD36CNBPCYP2E1CYP7A1HMGCRLDLRLEPRNR1H2NR1H3NR1H4PPARAPPARGPRKAA1 (AMPK)RXRASREBF1SREBF2
Other Lipid Metabolism & Transport Genes
ACACAACSL5ACSM3DGAT2FABP3FABP5FASNGKHNF4ALPLPNPLA3PPA1SCDSLC27A5
Oxidative Phosphorylation
ATP5F1CNDUFB6PPA1
Inflammatory Response
CEBPBFASIFNGIL10IL1BIL6NFKB1RXRATNF
Apoptosis
AKT1CASP3CEBPBFASMAPK1 (ERK2)MAPK8 (JNK1)NFKB1PIK3CA (p110-alpha)PPARGPRKAA1 (AMPK)RXRASERPINE1 (PAI-1)SOCS3TNF