Target List
Inflammasomes
AIM2
Casp1 (Ice)Pycard (Tms1, Asc)
IPAF
Casp1 (Ice)Naip6 (QuantiNova Symbol: AC135826.1)Nlrc4 (Ipaf)Pycard (Tms1, Asc)
NLRP1
Casp1 (Ice)Nlrp1a (Nalp1)
NLRP3
Casp1 (Ice)Nlrp3Pycard (Tms1, Asc)
Negative Regulation of Inflammasomes
Bcl2Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Bcl2l1 (Bcl-xl)Cd40lgCtsbHsp90aa1Hsp90ab1Hsp90b1LOC103689974 (Tnfsf11)LOC103694380 (Tnf)MefvPstpip1Sugt1Tnfsf14Tnfsf4 (Ox40l)
Signaling Downstream of Inflammasomes
IfngIl12aIl12bIl18Il1bIl33Irak1Irf1MokMyd88P2rx7Panx1Ptgs2 (Cox2)Ripk2Txnip
NOD-Like Receptors
NOD-Like Receptors
CiitaNaip6 (QuantiNova Symbol: AC135826.1)Nlrc4 (Ipaf)Nlrp12Nlrp1a (Nalp1)Nlrp3Nlrp5Nlrp6Nlrx1Nod2
Signaling Downstream of NOD-Like Receptors
Birc2 (c-IAP2)Birc3 (c-IAP1)Card6Casp8 (Flice)Ccl11 (Eotaxin)Ccl12Ccl2 (Mcp-1)Ccl5 (Rantes)Ccl7 (Mcp-3)Cflar (Casper)Chuk (Ikbka, Ikka)Cxcl1Cxcl3FaddIfnb1Ikbkb (IKK2)IkbkgIl6Irf1Irf2Irf3Irf4Irf5Irf6LOC100910771 (Map3k7)LOC103694380 (Tnf)Mapk1 (Erk2)Mapk11 (p38beta)Mapk12 (Sapk3)Mapk13Mapk14 (p38alpha)Mapk3 (ERK1)Mapk8 (Jnk1)Mapk9 (Jnk2)Nfkb1Nfkbia (Iκbα, Mad3)Nfkbib (Trip9)Pea15RelaRipk2Sugt1Tab1Tab2TirapTraf6Xiap
Pro-Inflammatory Caspases
Casp1 (Ice)Casp12