Neurotrophin/TRK Signaling
Neurotrophins are growth factors that control survival, development and function of neurons in the central and peripheral nervous system. Four mammalian neurotrophins have been described: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Neurotrophins can bind members of the tropomyosin-related kinase (TRK) family of receptors as well as p75 neurotrophin receptor p75(NTR).TRKs are tyrosine kinases that are activated by the binding of neurotrophins. Signal transduction involves the recruitment of adapter molecules Shc, GRB2 and GAB1 which in turn activate the Ras/Raf/MEK/ERK pathway and the PI3K/AKT pathway...
Pathway Summary
Neurotrophins are growth factors that control survival, development and function of neurons in the central and peripheral nervous system. Four mammalian neurotrophins have been described: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Neurotrophins can bind members of the tropomyosin-related kinase (TRK) family of receptors as well as p75 neurotrophin receptor p75(NTR).TRKs are tyrosine kinases that are activated by the binding of neurotrophins. Signal transduction involves the recruitment of adapter molecules Shc, GRB2 and GAB1 which in turn activate the Ras/Raf/MEK/ERK pathway and the PI3K/AKT pathway. TRKs also activate PLCĪ³1 which increases intracellular Ca+2. Neurotrophin signaling via TRKs effects neuron proliferation and neurite outgrowth and differentiation.p75NTR is a member of the tumour necrosis factor receptor superfamily. Stimulation of p75NTR with neurotrophin can activate multiple downstream signals, including Rho-like GTPases Cdc42 and the stress activated kinase, JNK. p75NTR is involved in a diverse array of cellular responses, including apoptosis, growth and myelination.
Neurotrophin/TRK Signaling Genes list
Explore Genes related to Neurotrophin/TRK Signaling
AKT1AKT serine/threonine kinase 1 ATF2activating transcription factor 2 ATF4activating transcription factor 4 BDNFbrain derived neurotrophic factor CDC42cell division cycle 42 CREB1cAMP responsive element binding protein 1 CREB3cAMP responsive element binding protein 3 CREB3L1cAMP responsive element binding protein 3 like 1 CREB3L2cAMP responsive element binding protein 3 like 2 CREB3L3cAMP responsive element binding protein 3 like 3 CREB3L4cAMP responsive element binding protein 3 like 4 CREB5cAMP responsive element binding protein 5 CREBBPCREB binding protein CRYGAcrystallin gamma A ERASES cell expressed Ras FOSFos proto-oncogene, AP-1 transcription factor subunit FRS2fibroblast growth factor receptor substrate 2 GAB1GRB2 associated binding protein 1 GRB2growth factor receptor bound protein 2 HRASHRas proto-oncogene, GTPase JUNJun proto-oncogene, AP-1 transcription factor subunit KLK3kallikrein related peptidase 3 KRASKRAS proto-oncogene, GTPase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAP2K3mitogen-activated protein kinase kinase 3 MAP2K4mitogen-activated protein kinase kinase 4 MAP2K5mitogen-activated protein kinase kinase 5 MAP2K6mitogen-activated protein kinase kinase 6 MAP2K7mitogen-activated protein kinase kinase 7 MAP3K5mitogen-activated protein kinase kinase kinase 5 MAPK1mitogen-activated protein kinase 1 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPK8mitogen-activated protein kinase 8 MRASmuscle RAS oncogene homolog NGFnerve growth factor NGFRnerve growth factor receptor NRASNRAS proto-oncogene, GTPase NTF3neurotrophin 3 NTF4neurotrophin 4 NTRK1neurotrophic receptor tyrosine kinase 1 NTRK2neurotrophic receptor tyrosine kinase 2 NTRK3neurotrophic receptor tyrosine kinase 3 PDPK13-phosphoinositide dependent protein kinase 1 PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PLCG1phospholipase C gamma 1 PTPN11protein tyrosine phosphatase non-receptor type 11 RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RPS6KA1ribosomal protein S6 kinase A1 RRASRAS related RRAS2RAS related 2 SHC1SHC adaptor protein 1 SORCS1sortilin related VPS10 domain containing receptor 1 SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 SPRY1sprouty RTK signaling antagonist 1 SPRY2sprouty RTK signaling antagonist 2