Target List
Inflammasomes
AIM2
Aim2Casp1 (Ice)Pycard (Tms1, Asc)
IPAF
Casp1 (Ice)Naip1 (Birc1)Naip5Nlrc4 (Ipaf)Pycard (Tms1, Asc)
NLRP1
Casp1 (Ice)Nlrp1a
NLRP3
Casp1 (Ice)Nlrp3Pycard (Tms1, Asc)
Negative Regulation of Inflammasomes
Bcl2Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Bcl2l1 (Bcl-XL)Cd40lgCtsbHsp90aa1Hsp90b1MefvPstpip1Sugt1TnfTnfsf11 (Rankl)Tnfsf14Tnfsf4 (Ox40l)
Signaling Downstream of Inflammasomes
IfngIl12aIl12bIl18Il1bIl33Irak1Irf1Myd88P2rx7Panx1Ptgs2 (Cox2)MokRipk2Txnip
NOD-Like Receptors
NOD-Like Receptors
CiitaNaip1 (Birc1)Naip5Nlrc4 (Ipaf)Nlrc5Nlrp1aNlrp12 (Nalp12, PYPAF7)Nlrp3Nlrp4bNlrp4eNlrp5Nlrp6Nlrp9bNlrx1Nod1Nod2
Signaling Downstream of NOD-Like Receptors
Birc2 (cIAP1, cIAP2)Birc3 (cIAP1, cIAP2)Card6Casp8 (Flice)Ccl12 (MCP-5, Scya12)Ccl5 (Rantes)Ccl7 (mcp3)Cflar (Casper)Chuk (IKBKA)Cxcl3Cxcl1 (Gro1)FaddIfnb1Ikbkb (IKKbeta)IkbkgIl6Irf1Irf3Irf4Map3k7 (Tak1)Mapk1 (Erk2)Mapk11 (p38beta)Mapk12 (P38Gamma)Mapk13 (SAPK4, Serk4)Mapk3 (Erk1)Mapk8 (Jnk1)Mapk9 (Jnk2)Nfkb1Nfkbia (Iκbα, Mad3)Nfkbib (Trip9)Pea15aRelaRipk2Sugt1Tab1Tab2TirapTnfTraf6Xiap
Pro-Inflammatory Caspases
Casp1 (Ice)Casp12