Target List
AKT & PI3 Kinase Family Members & Their Regulators
AKT1AKT2AKT3BTKGRB10GRB2HSPB1ILKMTCP1PDK2PDPK1PIK3CAPIK3CGPIK3R1PIK3R2PAK1PRKCAPRKCBPRKCZPTENTCL1A
IGF-1 Signaling
CSNK2A1ELK1FOSGRB2HRASIGF1IGF1RIRS1JUNMAP2K1MAPK3MAPK8PTPN11RAF1RASA1SHC1SOS1SRF
GSK3 Inactivation & β-Catenin Accumulation
ADARAKT1APCCCND1CD14CTNNB1EIF2AK2GJA1GSK3BIRAK1MYD88NFKB1PDK1TIRAPTLR4TOLLIP
Cytoskeleton Regulators
CDC42PDGFRARAC1RHOAWASL
PTEN-Dependent Cell Cycle Arrest & Apoptosis
AKT1CDKN1BFASLGFOXO3GRB2ILKITGB1MAPK1MAPK3PDK1PDK2PTENPTK2RBL2SHC1SOS1
BAD Phosphorylation & Anti-Apoptotic Pathways
AKT1BADGRB2HRASIGF1RIRS1MAP2K1MAPK1MAPK3RAF1RPS6KA1SHC1SOS1YWHAH
mTOR Signaling
AKT1EIF4BEIF4EEIF4EBP1EIF4G1FKBP1AMTORPDK1PDK2PTENRHEBRPS6KB1TSC1TSC2
Regulation of eIF4e & p70 S6 Kinases
AKT1EIF4EEIF4EBP1EIF4G1MTORIRS1MAPK1MAPK14MAPK3PABPC1PDK1PDK2PRKCAPTEN
Regulation of Adipogenesis
RPS6KB1
Other AKT Signaling Genes
CASP9CHUKFOXO1NFKBIA