Target List
Toll-Like Receptors
Muc13Tlr1Tlr2Tlr3Tlr4Tlr5Tlr6Tlr7Tlr8Tlr9
Pathogen-Specific Responses
Bacterial Response
Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Cd14FosHrasIl10Il12aIl1bIl6Irak1Hmgb1Hspa1a (hsp70A1)JunLta (Tnfb)Ly86 (MD-1)Ly96 (MD-2)Nfkbia (Iκbα, Mad3)Pglyrp1Ptgs2 (Cox2)RelaRipk2Tlr2Tlr4Tlr6Tnfrsf1a (Tnfr1)Ticam1 (Trif)
Viral Response
Eif2ak2Ifnb1IfngIl12aIl6Irf3RelaTbk1Tlr3Tlr7Tlr8TnfTicam1 (Trif)
Fungal / Parasitic Response
Clec4eHrasHspa1a (hsp70A1)Tlr2Tirap
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
Tollip
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
Irf3Map3k7 (Tak1)Nr2c2 (TAK1)Peli1Tbk1Ticam2Tlr3Tlr4Traf6Ticam1 (Trif)
MYD88-Dependent Signaling
Irak1Irak2Map3k7 (Tak1)Myd88Nr2c2 (TAK1)TirapTlr1Tlr2Tlr4Tlr5Tlr6Tlr7Tlr8Tlr9Traf6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
BtkCasp8 (Flice)Chuk (IKBKA)FaddAgfg1Ikbkb (IKKbeta)Il1r1Il10Il1bIrak1Irak2Irf3Ly96 (MD-2)Map3k1 (Mekk1)Map3k7 (Tak1)Nfkb1Nfkb2Nfkbia (Iκbα, Mad3)Nfkbib (Trip9)Nfkbil1NfrkbPparaRelRelaTnfTnfaip3Tnfrsf1a (Tnfr1)TraddUbe2nUbe2v1
JNK / p38 Signaling
Elk1FosIl1bJunMap2k3 (Mek3)Map2k4 (Mkk4, Jnkk1)Map3k1 (Mekk1)Map3k7 (Tak1)Mapk8 (Jnk1)Mapk8ip3 (Jip3)Mapk9 (Jnk2)Tnf
JAK / STAT Signaling
Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)Csf2 (GMCSF)IfngIl12aIl2Il6
Interferon Regulatory Factor (IRF) Signaling
Cxcl10 (Inp10)Ifnb1IfngIrf1Irf3Tbk1
Cytokine Signaling
Ccl2 (MCP-1)Ccl2 (MCP-1)Ccl2 (MCP-1)CebpbCsf3 (Gcsf)Il1aIl1bIl1r1Il6Il6raIrak1Irak2RelaTnfTnfrsf1a (Tnfr1)
Regulation of Adaptive Immunity
Cd80Cd86Hspd1IfngIl10Il12aIl1bIl2Map3k7 (Tak1)Traf6
Toll-Like Receptor Interacting Proteins & Adaptors
BtkCd14Hmgb1HrasHspa1a (hsp70A1)Hspd1Ly86 (MD-1)Ly96 (MD-2)Mapk8ip3 (Jip3)Myd88Peli1Pglyrp1Ripk2Ticam1 (Trif)Ticam2TirapTollip
Downstream Effectors of Toll-Like Receptor Signaling
Casp8 (Flice)Eif2ak2FaddIrak1Irak2Map3k7 (Tak1)Nr2c2 (TAK1)PparaTraf6Ube2nUbe2v1