Target List
Skeletal Development
Cartilage Condensation
BMP1BMPR1B (ALK6)COL2A1SOX9
Ossification
ACVR1 (ALK2)AHSGBGLAPBMP1BMP2BMP3BMP4BMP5BMP6BMP7BMPR1A (ALK3)BMPR1B (ALK6)BMPR2CDH11CHRDCOL1A1COL2A1CSF1 (MCSF)CTSKDLX5EGFR (ERBB1)FGF2 (BFGF)FGFR2GDF10 (BMP3B)GLI1IGF1IGF1RIGF2IHHMMP2MMP8MMP9NOGRUNX2SMAD1 (MADH1)SMAD3 (MADH3)SOX9SP7SPP1TGFB1TGFB2TGFB3TNFSF11 (RANKL)TWIST1
Osteoclast Differentiation
BGLAPCSF1 (MCSF)TNFTNFSF11 (RANKL)
Osteoblast Differentiation
ACVR1 (ALK2)BGLAPBMP2BMP4BMP6BMP7BMPR1A (ALK3)BMPR1B (ALK6)BMPR2CHRDCOL1A1DLX5FGF2 (BFGF)FGFR2GDF10 (BMP3B)GLI1IGF1IHHNOGRUNX2SMAD1 (MADH1)SMAD3 (MADH3)SP7SPP1TWIST1
Other Skeletal Development Genes
ALPLCOMPFGFR1TGFBR1 (ALK5)TGFBR2
Bone Mineral Metabolism
Bone Mineralization
ACVR1 (ALK2)AHSGBGLAPBMP2BMP4BMP6BMP7BMPR1A (ALK3)BMPR1B (ALK6)BMPR2FGFR2IGF1SMAD3 (MADH3)SOX9TGFB1TGFB3TWIST1
Calcium Ion Binding & Homeostasis
ANXA5BGLAPCALCRCDH11COMPEGFFGF2 (BFGF)ITGB1MMP2MMP8TGFB1VDR
Extracellular Matrix (ECM) Molecules
Collagens
COL10A1COL14A1COL15A1COL1A1COL1A2COL2A1COL3A1COL5A1
Extracellular Matrix (ECM) Protease Inhibitors
AHSGSERPINH1 (HSP47)
Extracellular Matrix (ECM) Proteases
CTSKMMP10MMP2MMP8MMP9PHEX
Other Extracellular Matrix (ECM) Molecules
ALPLBGNFLT1 (VEGFR1)
Cell Adhesion Molecules
Cell-Cell Adhesion
BMP1BMPR1B (ALK6)CDH11COL14A1COL2A1EGFR (ERBB1)ICAM1IHHITGB1SOX9TGFB1TNFTNFSF11 (RANKL)VCAM1
Cell-Extracellular Matrix (ECM) Adhesion
CD36COL3A1CSF1 (MCSF)ITGA1ITGA2ITGA3ITGAMITGB1SMAD3 (MADH3)
Other Cell Adhesion Molecules
BGLAPCOL15A1COL5A1COMPFN1TNF
Growth Factors
CSF2 (GM-CSF)CSF3 (GCSF)EGFFGF1FGF2 (BFGF)GDF10 (BMP3B)IGF1IGF2PDGFAVEGFAVEGFB
Transcription Factors
GLI1NFKB1RUNX2SMAD1 (MADH1)SMAD2 (MADH2)SMAD3 (MADH3)SMAD4 (MADH4)SMAD5 (MADH5)SOX9TWIST1