Target List
Up-Regulated in Hepatocellular Carcinoma
BCL2BIRC5CCND1CFLAR (CASPER)FZD7IGF2IRS1LEF1MCL1METNFKB1PIN1PTK2 (FAK)RAC1RHOASMAD7STAT3TCF4TGFATGFB1TNFSF10 (TRAIL)XIAP
Down-Regulated in Hepatocellular Carcinoma
BAXBIDCASP8 (FLICE)CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)DLC1FADDFASHHIPIGFBP1IGFBP3ITGB1PTENRB1SMAD4 (MADH4)SOCS1SOCS3TGFBR2TNFRSF10B (DR5)
Signal Transduction
Classical WNT Signaling
CCND1CDKN2A (P16INK4A)CTNNB1FZD7LEF1MTDHPIN1RB1SFRP2TCF4
TGFβ Signaling
SMAD4 (MADH4)SMAD7TGFB1TGFBR2
AKT & PI3 Kinase Signaling
AKT1IRS1PTEN
IGF / IGFR Signaling
IGF2IGFBP1IGFBP3IRS1
Hippo Signaling
YAP1
RAS / RAF / MAP Kinase Signaling
CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)DLC1HRASNRASRAC1RASSF1RB1RHOATP53 (p53)
EGFR Signaling
ADAM17 (CD156B)CDH13EGFEGFR (ERBB1)TGFATGFB1
MET / HGF Signaling
METHGF
G-Protein Signaling
CDH13CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)DAB2IPDLC1HRASNRASRAC1RASSF1RB1RELNRHOATP53 (p53)
Epithelial-to-Mesenchymal Transition (EMT)
CTNNB1HGFLEF1SMAD4 (MADH4)SMAD7TGFB1
Cell Cycle
BIRC5CCND1CCND2CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN2A (P16INK4A)E2F1EP300GADD45BIGF2MYCPTENRASSF1RUNX3
Apoptosis
BAXBCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BIDBIRC2 (c-IAP1)BIRC5CASP8 (FLICE)CFLAR (CASPER)DLC1E2F1EP300FADDFASFHITGADD45BGSTP1MCL1MSH2PYCARD (TMS1, ASC)RUNX3SOCS3TERTTNFRSF10B (DR5)TNFSF10 (TRAIL)WT1
Immune & Inflammatory Responses
CCL5 (RANTES)CXCR4NFKB1PTGS2 (COX2)RAC1TGFB1TLR4
Extracellular Matrix (ECM) & Cell Adhesion Molecules
ADAM17 (CD156B)AKT1CDH1 (E-Cadherin)CDH13CFLAR (CASPER)DLC1EGFR (ERBB1)EP300HGFITGB1LEF1OPCML (OBCAM)PTENPYCARD (TMS1, ASC)RAC1RELNRHOASMAD7SOCS1SOCS3TGFB1
Angiogenesis
ANGPT2CASP8 (FLICE)CDH13CTNNB1EGFFLT1 (VEGFR1)KDR (VEGFR3)PDGFRAPTENPTK2 (FAK)TGFBR2VEGFA
DNA Damage & Repair
CCND1CDKN1A (p21CIP1, WAF1)MSH2MSH3TP53 (p53)XIAP