Target List
Necrosis
Regulation of Necrosis
FASFASLG (TNFSF6)RIPK1SLC25A4TNF
TNF-Induced Necrosis
ATP6V1G2BMFC1orf159CCDC103COMMD4CYLDDEFB1DENND4ADPYSL4EIF5BFOXI1GALNT5GRB2HSPBAP1JPH3KCNIP1MACO1MAGOR10J3PARP2PVRRAB25S100A7ASPATA2SYCP2TXNL4B
Other Necrosis Genes
CD40 (TNFRSF5)FADDOGAPARP1 (ADPRT1)PPIARIPK1RIPK3SP1TMEM123
Potential Necrosis Genes
RIPK1 Interactors
FUSNFKB1RIPK2RIPK3
RIPK3 Interactors
GLUD1GLULPYGLRIPK1
PARP1 Interactors
CAPN1CAPN2CAPN3CAPN5CAPN6CAPN7CAPNS1PPID
Death Domain Receptors
FASTNFRSF10A (TRAIL-R)TNFRSF1A (TNFR1)
Death Receptor Signaling
BEX3BIDBIRC3 (c-IAP2)CASP8AP2CYLDEDA2RFADDFAF1FEM1BIKBKGMADDMYD88NGFNGFRPARP1 (ADPRT1)PIDD1 (PIDD)RIPK1TNFRSF14TNFRSF17TNFRSF1BTNFRSF25 (DR3)TNFRSF4 (OX40)TNFRSF8TNFSF15TRADDTRAF2
Apoptosis
Pro-Apoptotic
AIFM1BAXBEX3BIDBMFBNIP3LCASP8AP2FADDFAF1FASFASLG (TNFSF6)FEM1BIKBKGMADDNGFRPIDD1 (PIDD)RIPK1RIPK2RIPK3TNFTNFRSF10A (TRAIL-R)TNFRSF25 (DR3)TNFRSF8TNFSF10 (TRAIL)TRADDTRAF2
Anti-Apoptotic
BIRC3 (c-IAP2)BNIP3LFASMYD88NFKB1NGFNGFRRIPK1RIPK2TNFTNFRSF1A (TNFR1)TNFRSF1BTNFRSF4 (OX40)TRAF2
TNF-Induced Apoptosis
ATP6V1G2CYLDSPATA2SYCP2
Oxidative Stress
AIFM1CYBBGLUD1NOX1NOX4
Mitochondrial Genes
AIFM1BAXBIDBNIP3LCYBBGLUD1GLULPPIDRIPK1SLC25A4