Target List
Bone Remodeling & BMP Signaling
ADCY10ALOX12ALOX15ALOX5ALPLBGLAPBMP2CLCN7COL1A1COL1A2COMTCRTAPCTSKENPP1HSD11B1IGF1ITGA1ITGB3MMP2MTHFRNFATC1NOGNOS3 (eNOS)P2RX7PLOD2RUNX2SFRP1SOSTSPARCSPP1STAT1TIMP2TWIST1WNT10BWNT3A
Calciotropic Hormones & Receptors
ARCALCACALCRCASRCYP17A1CYP19A1DBPESR1 (ERα)ESR2 (ERβ)ESRRANR3C1 (GRL)PRLPTHPTH1RPTHLHSHBGTSHRVDR
Cytokines, Growth Factors & Receptors
BMP2BMP7CD40 (TNFRSF5)CNR2FGFR1FGFR2GHRHIGFBP2IL15IL6IL6RP3H1 (LEPRE1)LRP1LRP5LRP6LTA (TNFB)LTBP2MSTNNPYTGFB1TNFAIP3TNFRSF11A (RANK)TNFRSF11B (OPG)TNFRSF1BTNFSF11 (RANKL)VEGFA
Osteoblast Activity & Differentiation
ALPLBGLAPBMP2RUNX2
RANK / RANKL / OPG Signaling
TNFRSF11A (RANK)TNFRSF11B (OPG)TNFSF11 (RANKL)
WNT / β-Catenin Signaling
DKK1LRP1LRP5LRP6SFRP4SOSTTWIST1WNT10BWNT3A
Other Osteoporosis Genes
ACP5CA2LEP (Leptin)MAB21L2