Target List
mTOR Complexes
mTORC1 Complex
Mlst8MtorRptor
mTORC2 Complex
Mapkap1 (Sin1)Mlst8Mtor
mTOR Upstream Regulators
mTORC1 Negative Regulation
Akt1s1 (Pras40)Cab39Cab39lDdit4 (Redd1)Ddit4lFkbp1a (Fkbp12)Fkbp8Igfbp3Prkaa1 (Ampk)Prkaa2Prkab1Prkab2Prkag2Prkag3PtenStk11 (Lkb1)Tp53 (p53)Tsc1Tsc2Ywhaq (14-3-3θ)
mTORC1 Positive Regulation
Akt1Akt2Akt3HrasIgf1Ikbkb (IKK2)Ins2InsrIrs1KrasMapk1 (Erk2)Mapk3 (ERK1)NrasPdpk1Pik3c3 (Vps34)Pik3ca (p110-alpha)Pik3cbPik3cdPik3cgPik3r1 (PI3KA)Pik3r2Pld1Pld2RhebRps6ka1Rps6ka2Rps6ka4Rps6ka5RragaRragb (QuantiNova Symbol: LOC108348096)RragcRragd
mTORC2 Negative Regulation
Cab39Cab39lDdit4 (Redd1)Ddit4lPrkaa1 (Ampk)Prkaa2Prkab1Prkab2Prkag2Prkag3Stk11 (Lkb1)Tsc1Tsc2
mTORC2 Positive Regulation
Akt1Akt2Akt3Mapk1 (Erk2)Mapk3 (ERK1)Pdpk1Pik3c3 (Vps34)Pik3ca (p110-alpha)Pik3cbPik3cdPik3cgPik3r1 (PI3KA)Pik3r2RhebRps6ka1Rps6ka2Rps6ka4Rps6ka5
mTOR Downstream Effectors
mTORC1 Negative Regulation
Eif4ebp1Eif4ebp2LOC103694903 (Ppp2ca)Ppp2r2bTp53 (p53)Ulk1
mTORC1 Positive Regulation
Chuk (Ikbka, Ikka)Eif4bEif4eHif1aIkbkb (IKK2)LOC100911372 (Rps6)Rps6kb1Rps6kb2Tp53 (p53)VegfaVegfbVegfc
mTORC2 Positive Regulation
Akt1Cdc42Gsk3bHspa4 (Hsp70)IlkMyo1cPrkcaPrkcbPrkcePrkcgRhoaRps6kb1Sgk1
Cellular Processes Regulated by mTOR Signaling
Amino Acid Response
Pik3c3 (Vps34)RragaRragb (QuantiNova Symbol: LOC108348096)RragcRragd
Angiogenesis
Chuk (Ikbka, Ikka)Ddit4 (Redd1)Ddit4lHif1aIkbkb (IKK2)VegfaVegfbVegfc
Autophagy
Pik3c3 (Vps34)Ulk1
Cytoskeletal Organization
Cdc42PrkcaPrkcbPrkcePrkcgRhoa
Growth Factor Response
HrasIgf1Igfbp3KrasMapk1 (Erk2)Mapk3 (ERK1)NrasRps6ka1Rps6ka2Rps6ka4Rps6ka5
Energy Stress
Prkaa1 (Ampk)Prkaa2Prkab1Prkab2Prkag2Prkag3
Insulin Signaling
Akt1Akt2Akt3Ins2InsrIrs1Pdpk1Pik3ca (p110-alpha)Pik3cbPik3cdPik3cgPik3r1 (PI3KA)Pik3r2Tp53 (p53)
Lipid Metabolism
Pld1Pld2
Translation
Eif4bEif4eEif4ebp1Eif4ebp2LOC100911372 (Rps6)LOC103694903 (Ppp2ca)Ppp2r2bRps6ka1Rps6ka2Rps6ka4Rps6ka5Rps6kb1Rps6kb2
Other mTOR Signaling Genes
Kmt2dPtpa