Target List
Toll-Like Receptors
CD180SIGIRRTLR1TLR2TLR3TLR4TLR5TLR6TLR7TLR8TLR9TLR10
Pathogen-Specific Responses
Bacterial Response
CCL2CD14CD180FOSHRASIL10IL12AIL1BIL6CXCL8IRAK1HMGB1HSPA1AJUNLTALY86LY96NFKBIAPTGS2RELARIPK2TLR2TLR4TLR6TNFRSF1ATICAM1
Viral Response
EIF2AK2IFNB1IFNGIL12AIL6IRF3PRKRARELATBK1TLR3TLR7TLR8TNFTICAM1
Fungal / Parasitic Response
CLEC4EHRASHSPA1ACXCL8TLR2TIRAP
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
SARM1SIGIRRTOLLIP
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
IRF3MAP3K7TAB1NR2C2PELI1TBK1TICAM2TLR3TLR4TRAF6TICAM1
MYD88-Dependent Signaling
IRAK1IRAK2MAP3K7TAB1MYD88NR2C2TIRAPTLR1TLR10TLR2TLR4TLR5TLR6TLR7TLR8TLR9TRAF6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
BTKCASP8CHUKECSITFADDIKBKBIL10IL1BIRAK1IRAK2IRF3LY96MAP3K1MAP3K7MAP4K4NFKB1NFKB2NFKBIANFKBIL1NFRKBPPARARELRELATNFTNFRSF1AUBE2N
JNK / p38 Signaling
ELK1FOSIL1BJUNMAP2K3MAP2K4MAP3K1MAP3K7MAPK8MAPK8IP3TNF
JAK / STAT Signaling
CCL2CSF2IFNGIL12AIL2IL6
Interferon Regulatory Factor (IRF) Signaling
CXCL10IFNA1IFNB1IFNGIRF1IRF3TBK1
Cytokine Signaling
CCL2CSF3IL1AIL1BIL6IRAK1IRAK2RELASIGIRRTNFTNFRSF1A
Regulation of Adaptive Immunity
CD80CD86HSPD1IFNGIL10IL12AIL1BIL2MAP3K7TRAF6
Toll-Like Receptor Interacting Proteins & Adaptors
BTKCD14HMGB1HRASHSPA1AHSPD1LY86LY96MAPK8IP3MYD88PELI1RIPK2SARM1TICAM1TICAM2TIRAPTOLLIP
Downstream Effectors of Toll-Like Receptor Signaling
CASP8EIF2AK2FADDIRAK1IRAK2IRAK4MAP3K7TAB1NR2C2PPARAPRKRAECSITTRAF6UBE2N