Target List
Cytokines & Receptors
CCL5 (RANTES)CCL7 (MCP-3)CCR3CCR4CCR5CCR6IL12BIL12RB2IL13IL13RA1IL17AIL17REIL18IL18R1IL18RAPIL1R1IL1R2IL1RL1 (ST2)IL2IL21IL2RA (CD25)IL4IL4R (CD124)IL5IL9TNF
T Helper 1 Subtype Markers
CCR5HAVCR2IGSF6IL12BIL18IRF1SOCS1SOCS5TLR4TLR6TNF
T Helper 2 Subtype Markers
CCL5 (RANTES)CCL7 (MCP-3)CCR3CCR4CEBPBGFI1PTGDR2 (CRTH2, GPR44)ICOSIL13RA1IL4R (CD124)JAK1NFATC1NFATC2
Transcription Factors
CEBPBFOSL1 (FRA-1)FOXP3GATA3GATA4HOXA10HOXA3ID2IRF4IRF8MAFNFATC1NFATC2NR4A1 (NUR77)NR4A3 (NOR1)POU2F2RELRELBRORARORCRUNX1 (AML1)RUNX3STAT1STAT4STAT6TOXZBTB7B
Epigenetically Regulated Genes
Th1 Cells
EOMESIFNGIL12RB2IL18R1IL18RAPFASLG (TNFSF6)TBX21
Th2 Cells
ASB2GATA3IL13IL1RL1 (ST2)IL4IL5PPARG
Th17 Cells
IL17AIL17REIL1R1IL21RORARORC
Inducible & Natural Regulatory T (iTreg & nTreg) Cells
CCR6FOSL1 (FRA-1)FOXP3IKZF2IL9IRF4IRF8MYBNR4A1 (NUR77)NR4A3 (NOR1)POU2F2RELRELBTGIF1TNFSF11 (RANKL)
Conventional Versus Regulatory T-Cells
CACNA1FCHD7FOXP3GATA4HOPXHOXA10HOXA3ID2IKZF2IL1R2IL2RA (CD25)KIF2CLRRC32PERPPKD2TNFRSF9TP53INP1UTS2