Target List
EGFR Signaling
BCAR1CBLEGFEGFR (ERBB1)EPS8GAB1GRB2HBEGFNCK2NUP62RPS6KA5SHC1
Platelet-Derived Growth Factor Receptor Signaling
BCAR1PDGFAPDGFBPDGFRAPLAT (TPA)
Intracellular Signaling
AKT Signaling
AKT1AKT2AKT3BADCASP9CHUK (IKKα)FASLG (TNFSF6)FOXO3NFKB1PTEN
ERK1 / ERK2 Signaling
EGFR (ERBB1)ELK1GRB2MAP2K1MAPK1 (ERK2)MAPK3 (ERK1)MKNK1PDGFRARAF1RPS6KA5SHC1SRCSTAT3
IκB Kinase / NFκB Cascade
CHUK (IKKα)FASLG (TNFSF6)GSK3AGSK3BNUP62RHOASTAT1
JAK / STAT Signaling
EPS8GAB1GRB2JAK1NUP62PPP2CASRCSTAT1STAT3STAT5A
JNK / p38 Signaling
MAP2K4 (MKK4, JNKK1)MAP3K2 (MEKK2)MAPK10 (JNK3)MAPK8 (JNK1)MAPK9 (JNK2)
MAP Kinase Signaling
DUSP1 (PTPN16)DUSP6EGFEGFR (ERBB1)MAP2K1MAP2K7 (JNKK2)MAPK1 (ERK2)MAPK10 (JNK3)MAPK3 (ERK1)MAPK8 (JNK1)MAPK9 (JNK2)PPP2CAPRKCASHC1
PI3 Kinase Signaling
PIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PIK3R2 (p85-BETA)PTEN
G-Protein Signaling
GRB2HRASNRASNUP62RAP1ARASA1RHOA
Other Intracellular Signaling Molecules
ARAFBRAFCBLCSNK2A1CSNK2BIKBKB (IKKβ)NCK2PDPK1PLCG1RPS6KB1
Cell Survival & Growth
Apoptosis
AKT1BADBCAR1BCL2BRAFCASP3CASP9FASLG (TNFSF6)FOXO3IL2LTA (TNFB)MAPK1 (ERK2)NFKB1NUP62PIK3R2 (p85-BETA)PPP2CAPRKCAPTENRAF1RASA1STAT1TP53 (p53)
Cell Cycle
BCL2CCND1DUSP1 (PTPN16)DUSP6EGFR (ERBB1)HRASKRASMAPK1 (ERK2)MAPK3 (ERK1)NRASPDGFAPDGFBPPP2CAPRKCAPTENRAP1ASHC1STAT1TP53 (p53)
Cell Differentiation
FOXO3IL2PPP2CATP53 (p53)
Cell Growth
BCAR1CCND1EGFHBEGFIL2PDGFAPDGFBPDGFRAPPP2CARASA1SHC1TP53 (p53)
Cell Motility
ACTR2BCAR1EGFR (ERBB1)FN1HBEGFMAP2K1MAPK8 (JNK1)PTENSTAT3
Cell Proliferation
BCAR1BCL2EGFEGFR (ERBB1)EPS8GAB1HBEGFIL2NCK2NUP62PDGFAPDGFBPDGFRAPTENRAF1SHC1TP53 (p53)
Metabolism
DNA Metabolism
ATF1ATF2 (CREB2)CREB1EGFEGFR (ERBB1)FOSNUP62PPP2CATP53 (p53)
Lipid Metabolism
ARAFBRAFPIK3R1 (p85-ALPHA)PLCG1PPP2CAPRKCAPTENRAF1SHC1
Protein Metabolism
ACTR2AKT1AKT2AKT3ARAFATF1ATF2 (CREB2)BRAFCBLCHUK (IKKα)CREB1CSNK2A1DUSP1 (PTPN16)DUSP6EGFR (ERBB1)FOSGSK3AGSK3BIKBKB (IKKβ)JAK1MAP2K1MAP2K4 (MKK4, JNKK1)MAP2K7 (JNKK2)MAP3K2 (MEKK2)MAPK1 (ERK2)MAPK10 (JNK3)MAPK3 (ERK1)MAPK8 (JNK1)MAPK9 (JNK2)MKNK1PDGFRAPDPK1PPP2CAPRKCAPTENRAF1RPS6KA5RPS6KB1SRC
Other Metabolism Genes
COL1A1EIF4EFN1MMP7RASA1
Development
BRAFCOL1A1HBEGFPTENRASA1STAT3
Stimulus Response
Response to Wounding
BCAR1BCL2FN1HBEGFIL2NCK2NFKB1PDGFBSTAT3
Response to Other Stimuli
AKT1CHUK (IKKα)COL1A1DUSP1 (PTPN16)EGFR (ERBB1)FASLG (TNFSF6)FOSKRASLTA (TNFB)MAP2K1MAP2K7 (JNKK2)MAPK1 (ERK2)MAPK8 (JNK1)MAPK9 (JNK2)NFATC3PPP2CARPS6KA5STAT1STAT5ATP53 (p53)
Transcription Factors & Regulators
AKT1ATF1ATF2 (CREB2)CBLCREB1EGR1EIF4EELK1FOSFOXO3IKBKB (IKKβ)JUNMKNK1NFATC3NFKB1NUP62PPP2CARPS6KA5STAT1STAT3STAT5ATP53 (p53)
Actin & Calcium Ion Homeostasis
ACTR2BCAR1CBLEGFEGFR (ERBB1)MMP7NCK2PDPK1PLCG1PRKCARASA1RHOASTAT1STAT3STAT5A