Target List
Apoptosis
AKT1BCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CASP8 (FLICE)CASP9FASLG (TNFSF6)
Necrosis
CYLDGRB2MAGPARP2PVRTXNL4B
DNA Damage & Repair
ATMBRCA1CDKN1A (p21CIP1, WAF1)ERCC2 (XPD)MDM2RAD51
Mitochondrial Energy Metabolism
ARRDC3ASB1CYB561D1DNAJB1HSPA1A (HSP70-1A)HSPA1BSLC25A25
Fatty Acid Metabolism (β-Oxidation)
ACADMACADVLACOX1CPT1ACPT1BCPT2
Oxidative Stress & Antioxidant Response
AKR1C2FHL2GCLMHMOX1NCOA7NQO1SLC7A11
Heat Shock Response
HSF1 (TCF5)HSP90B1HSPA4 (HSP70)HSPA8HSPB1 (HSP27)HSPD1
Endoplasmic Reticulum Stress & Unfolded Protein Response
ADM2ASNSDNAJB9HERPUD1INHBETRIB3 (SKIP3)UHRF1
Cytochrome P450s & Phase I Drug Metabolism
CYP1A2CYP2B6CYP2C19CYP2C9CYP2D6
Steatosis
CD36FASNLPLPPARASCDSREBF1
Cholestasis
ABCB4ABCC2 (MRP2, cMOAT)ABCC3 (MRP3, MOAT-D)ATP8B1SLC51APDYNRDX
Phospholipidosis
ASAH1HPNLSSSERPINA3SLC2A3TAGLNWIPI1
Immunotoxicity
ADH1CF2 (Thrombin)HPXLYZMETAP2MKI67NR5A2TRIM10