icon_0328_cc_gen_hmr_bacteria-s

Hypusine Biosynthesis

The eukaryotic translation initiation factor 5A (eIF-5A) must be activated by post translational modification before it can participate in the initiation of protein synthesis. The modification involves the addition of a butylamine residue (derived from spermidine) to a highly conserved lysine in the eIF-5A protein. This results in the formation of an unusual amino acid called hypusine. The biosynthesis of hypusine occurs exclusively within the eIF-5A precursor, and is catalyzed by two enzymatic steps, deoxyhypusine synthase (DHS) and Deoxyhypusine hydroxylase (DOHH). The strict substrate specificity for hypusine modification provides possible drug targeting of these enzymes, particularly in aberrant cell proliferation (

Hypusine Biosynthesis

Pathway Summary

The eukaryotic translation initiation factor 5A (eIF-5A) must be activated by post translational modification before it can participate in the initiation of protein synthesis. The modification involves the addition of a butylamine residue (derived from spermidine) to a highly conserved lysine in the eIF-5A protein. This results in the formation of an unusual amino acid called hypusine. The biosynthesis of hypusine occurs exclusively within the eIF-5A precursor, and is catalyzed by two enzymatic steps, deoxyhypusine synthase (DHS) and Deoxyhypusine hydroxylase (DOHH). The strict substrate specificity for hypusine modification provides possible drug targeting of these enzymes, particularly in aberrant cell proliferation (17476569).

Products related to Hypusine Biosynthesis

Explore products related to Hypusine Biosynthesis
GeneGlobe ID: PAHS-130Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Amino Acid Metabolism II
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-129Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Amino Acid Metabolism I
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: UPHS-130Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Amino Acid Metabolism II
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-130Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Amino Acid Metabolism II
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-129Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Amino Acid Metabolism I
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-129Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Amino Acid Metabolism I
QuantiNova LNA PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.