icon_0328_cc_gen_hmr_bacteria-s

PI3K/AKT Signaling

Phosphatidylinositol 3 kinases (PI3K) are a family of lipid kinases whose inositol lipid products play a central role in signal transduction pathways of cytokines, growth factors and other extracellular matrix proteins. PI3Ks are divided into three classes: Class I, II and III with Class I being the best studied one. It is a heterodimer consisting of a catalytic and regulatory subunit. These are most commonly found to be p110 and p85. Phosphorylation of phosphoinositide(4,5)bisphosphate (PIP2) by Class I PI3K generates PtdIns(3,4,5)P3...

PI3K/AKT Signaling

Pathway Summary

Phosphatidylinositol 3 kinases (PI3K) are a family of lipid kinases whose inositol lipid products play a central role in signal transduction pathways of cytokines, growth factors and other extracellular matrix proteins. PI3Ks are divided into three classes: Class I, II and III with Class I being the best studied one. It is a heterodimer consisting of a catalytic and regulatory subunit. These are most commonly found to be p110 and p85. Phosphorylation of phosphoinositide(4,5)bisphosphate (PIP2) by Class I PI3K generates PtdIns(3,4,5)P3.The different PI3ks are involved in a variety of signaling pathways. This is mediated through their interaction with molecules like the receptor tyrosine kinases (RTKs), the adapter molecules GAB1-GRB2, and the kinase JAK. These converge to activate PDK1 which then phosphorylates AKT. AKT follows two distinct paths: 1) Inhibitory role - for example, AKT inhibits apoptosis by phosphorylating the Bad component of the Bad/Bcl-XL complex, allowing for cell survival. 2) Activating role - AKT activates IKK leading to NF-κB activation and cell survival. By its inhibitory as well as activating role, AKT is involved in numerous cellular processes like energy storage, cell cycle progression, protein synthesis and angiogenesis.

PI3K/AKT Signaling Genes list

Explore Genes related to PI3K/AKT Signaling

Products related to PI3K/AKT Signaling

Explore products related to PI3K/AKT Signaling
GeneGlobe ID: PAHS-013Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Extracellular Matrix & Adhesion Molecules
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-150Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cytokines & Chemokines
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-058Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human PI3K-AKT Signaling Pathway
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: SBHS-150Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-058Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human PI3K-AKT Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-160Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human IL6/STAT3 Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-013Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Extracellular Matrix & Adhesion Molecules
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-013Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Extracellular Matrix & Adhesion Molecules
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-150Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-058Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human PI3K-AKT Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-025Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human NFkB Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-025Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human NFkB Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-160Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human IL6/STAT3 Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.