Target List
Senescence Pathway
AtmBmi1Ccnd1Ccne1Cdk2Cdk4Cdk6Cdkn1aCdkn2aChek2E2f1E2f3Ets1Ets2Mdm2Nuak1Rb1Rbl2Tp53Twist1
Senescence Initiators
p53 / pRb Signaling & the Cell Cycle
Akt1Aldh1a3Ccna2Ccnb1Cdc25cCdkn1cCdkn2bCdkn2cCited2Creg1Gsk3bId1Igf1rIgfbp3Ing1LOC100909750Map2k6Mapk14Morc3MycPcnaPik3caPlauRbl1Serpinb2Serpine1Sirt1SparcTgfb1
Interferon Signaling
Aldh1a3Cdkn1aCdkn1bEgr1IfngIgfbp3Igfbp7Irf3Irf5Irf7Nfkb1Rb1Serpinb2
Insulin Growth Factor (IGF) Related
Igf1Igf1rIgfbp3Igfbp5Igfbp7
MAP Kinase Signaling
HrasMap2k1Map2k3Map2k6Mapk14
Oxidative Stress
Aldh1a3HrasMapk14Nox4PrkcdSod1Sod2
DNA Damage & Repair
AtmGadd45aNbnPcnaTerf2TertTp53bp1
Senescence Responses
p53 Effectors
Aldh1a3E2f1HrasIgfbp3Myc
p21 Effectors
Calr
p16 Effectors
Tbx2Tbx3
Cytoskeleton Regulators
Akt1Fn1HrasPik3caPlauSerpine1SparcThbs1Vim
Cell Adhesion Molecules
Cd44Col1a1Col3a1Tgfb1Tgfb1i1Thbs1
Other Senescence Response Genes
Glb1PtenStt3a