Target List
JAK / STAT Signaling
Janus Kinases
JAK1JAK2JAK3TYK2
STAT Family Members
STAT1STAT2STAT3STAT4STAT5ASTAT5BSTAT6
JAK / STAT Signaling Regulators
PIAS1PIAS2PRLPTPN1PTPRCSOCS1SOCS2SOCS3SOCS4SOCS5
Cell Surface Receptors
CSF1REGFREPORF2RGHRIFNAR1IFNGR1IL10RAIL2RAIL2RGIL4RIL6STINSRMPLPDGFRASH2B1
SH3 / SH2 Adaptor Proteins
CRKGRB2SRCSTAM
STAT-Interacting Transcription Factors & Regulators
Transcriptional Regulation
HMGA1SMAD3SPI1
Transcription Factors
JUNBSP1USF1
Transcriptional Coactivators & Corepressors
JUNBPIAS1SMAD1SMAD5SP1YY1
Other Transcription Factors & Regulators
CEBPBCRKGATA3IRF1IRF9JUNMYCNFKB1NR3C1SMAD2SMAD4
STAT-Induced
STAT1-Induced
CXCL9IRF1JUNBNOS2
STAT3-Induced
A2MBCL2L1BCL2L1BCL2L1CCND1CDKN1ACEBPDCRPFASIRF1LRG1MCL1MYCSOCS1SOCS3
STAT4-Induced
FCGR1AIFNGIRF1MYC
STAT5-Induced
BCL2L1BCL2L1BCL2L1CCND1CDKN1AIL2RAIRF1OSM
STAT6-Induced
FCER2GATA3IL4IL4R
STAT1 / STAT2 / p48 Induced
ISG15OAS1
Apoptosis
AKT1BCL2L1BCL2L1BCL2L1CDKN1AF2F2RFASIL2RAMCL1NFKB1PRLRSTAT1
Cell Growth and / or Maintenance
Cell Cycle
CCND1CDKN1AEGFRF2F2RIL2RAIRF1JAK2MYCSTAT1
Cell Growth
A2MEGFRGHRIFNGIL4INSROSMSOCS1SOCS2SOCS3SOCS4SOCS5
Cell Proliferation
CSF1RIL2RGIL4MPLOSMPDGFRASMAD3
Cell Differentiation
IL20IL4NOS2SOCS2SOCS5
Immune Response
Acute-Phase Response
CEBPBCRPF2STAT3
Humoral Immune Response
CSF1RFCER2IL4NFKB1YY1
Inflammatory Response
CEBPBCRPCXCL9IL20NFKB1NOS2NR3C1
Other Immune Response Genes
CXCL9FASFCGR1AIFNGIL2RAIL2RGIL4RIL6STIRF1IRF9ISG15OAS1OSMPRLRPTPN11STUB1