Target List
Up-Regulated in Hepatocellular Carcinoma
BCL2BIRC5CCND1CFLARFZD7IGF2IRS1LEF1MCL1METNFKB1PIN1PTK2RAC1RHOASMAD7STAT3TCF4TGFATGFB1TNFSF10XIAP
Down-Regulated in Hepatocellular Carcinoma
BAXBIDCASP8CDKN1ACDKN2ADLC1FADDFASHHIPIGFBP1IGFBP3ITGB1PTENRB1SMAD4SOCS1SOCS3TGFBR2TNFRSF10B
Signal Transduction
Classical WNT Signaling
CCND1CDKN2ACTNNB1FZD7LEF1MTDHPIN1RB1SFRP2TCF4
TGFβ Signaling
SMAD4SMAD7TGFB1TGFBR2
AKT & PI3 Kinase Signaling
AKT1IRS1PTEN
IGF / IGFR Signaling
IGF2IGFBP1IGFBP3IRS1
Hippo Signaling
YAP1
RAS / RAF / MAP Kinase Signaling
CDKN1ACDKN2ADLC1HRASNRASRAC1RASSF1RB1RHOATP53
EGFR Signaling
ADAM17CDH13EGFEGFRTGFATGFB1
MET / HGF Signaling
METHGF
G-Protein Signaling
CDH13CDKN1ACDKN2ADAB2IPDLC1HRASNRASRAC1RASSF1RB1RELNRHOATP53
Epithelial-to-Mesenchymal Transition (EMT)
CTNNB1HGFLEF1SMAD4SMAD7TGFB1
Cell Cycle
BIRC5CCND1CCND2CDKN1ACDKN1BCDKN2AE2F1EP300GADD45BIGF2MYCPTENRASSF1RUNX3
Apoptosis
BAXBCL2BCL2L1BCL2L1BCL2L1BIDBIRC2BIRC5CASP8CFLARDLC1E2F1EP300FADDFASFHITGADD45BGSTP1MCL1MSH2PYCARDRUNX3SOCS3TERTTNFRSF10BTNFSF10WT1
Immune & Inflammatory Responses
CCL5CXCR4NFKB1PTGS2RAC1TGFB1TLR4
Extracellular Matrix (ECM) & Cell Adhesion Molecules
ADAM17AKT1CDH1CDH13CFLARDLC1EGFREP300HGFITGB1LEF1OPCMLPTENPYCARDRAC1RELNRHOASMAD7SOCS1SOCS3TGFB1
Angiogenesis
ANGPT2CASP8CDH13CTNNB1EGFFLT1KDRPDGFRAPTENPTK2TGFBR2VEGFA
DNA Damage & Repair
CCND1CDKN1AMSH2MSH3TP53XIAP