Target List
Up-Regulated in Nephrotoxicity
Apoptosis
Angptl4Anxa5Btg2Cd24Cd44Cdkn1aCluGadd45aGstp1Hmox1Nqo1Rtn4Socs3Tnfrsf12a
Cell Cycle
Ccnd1Ccng1Cdkn1aGadd45aMcm6
Metal Ion Binding
Bmp1CcsCpCtssHmox1Hmox2Mt1a
Oxidative Stress
CluG6pdGpx8Hmox1Hmox2Nqo1
Cell Proliferation
Atf3Btg2Ccnd1Cd24Cdkn1aCluCxcl1Cxcl10Cxcl3GlulGpnmbHmox1Hsp90aa1Timp1Uchl1Vcam1
Tissue Remodeling
Cst3Fn1Havcr1Spp1Timp1
Transporters
Abcb1aAbcc2
Xenobiotic Metabolism
Cyp2c11Gstp1
Extracellular Matrix (ECM) Molecules
Angptl4Ccl3Cd44Cst3FgbLgals3MgpTimp1
Cytoskeleton Regulators
Ccl3G6pdSprr1aTmsb10Vim
Other Genes Up-Regulated in Nephrotoxicity
GcIgfbp1Lcn2LOC100911545Ugt1a3
Down-Regulated in Nephrotoxicity
Apoptosis
Bmp4CatGhrIgfbp3Sod2
Cell Cycle
Bmp4Egf
Metal Ion Binding
BhmtIdh1RgnScd2Sod2Sod3
Oxidative Stress
CatGatmIdh1Sod2Sod3
Cell Proliferation
Bmp4EgfIgfbp3Nox4Odc1Sod2
Transporters
Slc22a1Slc22a5Slc22a6
Xenobiotic Metabolism
Cyp2d4Fmo2Gstk1
Extracellular Matrix (ECM) Molecules
Bmp4Ccn1Sod3
Other Genes Down-Regulated in Nephrotoxicity
AassAldh1a1Calb1G6pcGamtIpmkKlk1Nphs2Oat