Target List
MYC & Co-Transcription Factors
E2F1MAXMAZMYCLMYCNPIAS2
Up-Regulated by MYC
AIMP2APEX1ATF4BAXBCAT1CADCBX3CCNB1CCND2CCT5CDC25ACDK4CHEK1CKS2CSTBCTSCDDX10DKC1E2F1EIF4A1EIF4BEIF4EENO1EXOSC8FASNGNL3HK2HNRNPA1HNRNPA2B1LTA4HMAT2AMGST1MSH2MTHFD1NAP1L1NBNNCLNME1 (NM23)NOLC1NPM1ODC1PA2G4PAICSPCNAPHBPOLD2PPATPSMG1PTENPYCR1RPL13RPL19RPL23RPL27ARPL5RPS5SHMT1SNRPBSRMSRSF1TERTTOP1TP53 (p53)TPI1TYMSUBE2CYBX3
Down-Regulated by MYC
CDKN1B (P27KIP1)CDKN2B (p15INK4b)CSDE1ID3ILKITGB1MYCPTPAZFP36L1
Apoptosis
BAXCCNB1GNL3NPM1TP53 (p53)
Cell Cycle
CCNB1CCND2CDC25ACDK4CDKN1B (P27KIP1)CDKN2B (p15INK4b)GNL3PA2G4PCNATP53 (p53)
Cell Growth & Proliferation
CDKN1B (P27KIP1)CKS2NPM1PA2G4PCNAPHB
Chromatin Modifying & Associated Proteins
CBX3NAP1L1
DNA Repair
AIMP2APEX1CHEK1MSH2NBNNPM1PCNATERTTP53 (p53)
DNA Replication
PCNAPOLD2TOP1
Extracellular Matrix (ECM) & Cell Adhesion Molecules
ILKITGB1
Metabolism
BCAT1CADENO1FASNGCLCHK2LTA4HMAT2AMGST1MTHFD1NME1 (NM23)ODC1PAICSPDK1PPATPYCR1SHMT1SRMTPI1TYMS
Protein Synthesis, Degradation & Turnover
CCT5CSTBCTSCEIF4A1EIF4BEIF4ENCLNPM1PSMG1PYCR1RPL13RPL19RPL23RPL27ARPL5RPS5UBE2C
RNA Processing & Binding Factors
CSDE1DDX10DDX39BDKC1EXOSC8HNRNPA1HNRNPA2B1NOLC1SNRPBSRSF1
Signal Transduction
ILKNPM1PDK1PTENPTPA
Transcription Factors & Cofactors
ATF4ID3MYCTP53 (p53)YBX3ZFP36L1
Tumor Suppressor Genes
MSH2PHBTP53 (p53)