Target List
Genomic Instability
BUB1BMRPL43POLRMTTFAMTFB1MTFB2MZMPSTE24
Telomere Attrition
POT1RAP1ATERF1TERF2TINF2TPP1
Mitochondrial Dysfunction
MRPL43NDUFB11POLRMTSIRT1SIRT3SIRT6TFAMTFB1MTFB2M
Proteostasis
ARL6IP6BUB1BFOXO1HSF1 (TCF5)JAKMIP3RNF144BSIRT1TXNIPVPS13C
Laminopathies
LMNALMNB1LMNB2ZMPSTE24
Neurodegeneration & Synaptic Transmission
CALB1GFAPMBPSCN2BSNAP23
Epigenetic Alterations
ARID1ASIRT1SIRT3SIRT6
DNA Binding
ARID1AELP3EP300FBXL16ZBTB10ZFRZNF25
RNA Binding
ELAVL1LSM5ZFR
Inflammatory Response
ANGEL2ANXA3ANXA5C1QAC1QBC1QCC1SC3C3AR1C5AR1 (GPR77)CCR1CD14CD163CFHCX3CL1CXCL16FCER1GFCGBPFCGR1AFCGR2AFCGR3BGFAPLTFLYZMBPPANX1S100A8S100A9TMEM135TMEM33TLR2TLR4TOLLIP
Apoptosis
CASP1 (ICE)CLUEP300PDCD6TOLLIP
Cellular Senescence
CDKN1C (p57Kip2)VWA5AWRN
Cell Cycle
BUB1BCDKN1C (p57Kip2)
Cytoskeleton Regulators
COL1A1COL3A1EML1
Oxidative Stress
EP300GSTA1
Transcriptional Regulation
ARID1AEP300FOXO1HSF1 (TCF5)PHF3SMAD2 (MADH2)