Target List
Pro-Fibrotic
ACTA2 (α-SMA)AGTCCL11 (Eotaxin)CCL2 (MCP-1)CCL3 (MIP-1A)CCN2GREM1IL13IL13RA2IL4IL5SNAI1 (SNAIL)
Anti-Fibrotic
BMP7HGFIFNGIL10IL13RA2
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Extracellular Matrix (ECM) Structural Constituents
COL1A2COL3A1
Extracellular Matrix (ECM) Remodeling Enzymes
LOXMMP1MMP13MMP14MMP2MMP3MMP8MMP9PLAT (TPA)PLAU (UPA)PLGSERPINA1SERPINE1 (PAI-1)SERPINH1 (HSP47)TIMP1TIMP2TIMP3TIMP4
Cell Adhesion Molecules
ITGA1ITGA2ITGA3ITGAVITGB1ITGB3ITGB5ITGB6ITGB8
Inflammatory Cytokines & Chemokines
CCL11 (Eotaxin)CCL2 (MCP-1)CCL3 (MIP-1A)CCR2CXCR4IFNGIL10IL13IL13RA2IL1AIL1BIL4IL5ILKTNF
Growth Factors
AGTCCN2EDN1EGFHGFPDGFAPDGFBVEGFA
Signal Transduction
TGFβ Superfamily Members
BMP7CAV1DCNENG (EVI-1)GREM1INHBELTBP1SMAD2 (MADH2)SMAD3 (MADH3)SMAD4 (MADH4)SMAD6SMAD7TGFB1TGFB2TGFB3TGFBR1 (ALK5)TGFBR2TGIF1THBS1 (TSP-1)THBS2
Transcription Factors
CEBPBJUNMYCNFKB1SP1STAT1STAT6
Epithelial-to-Mesenchymal Transition (EMT)
AKT1BMP7COL1A2COL3A1ILKITGAVITGB1MMP2MMP3MMP9SERPINE1 (PAI-1)SMAD2 (MADH2)SNAI1 (SNAIL)TGFB1TGFB2TGFB3TIMP1
Other Fibrosis Genes
BCL2FASLG (TNFSF6)