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GeneGlobe ID: JHS-001Z | Cat. No.: | QIAseq RNA Fusion XP Panels

RNA Fusion XP Leukemia Panel

Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq

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Product Specification

Target List

Acute Leukemia of Ambiguous Lineage
ABL1AFF1BCRCT45A2ETV6EWSR1GPHNKMT2AMLLT10MN1NUP214PBX1SETTCF3ZNF384
Acute Lymphoblastic Leukemia (ALL)
ABL1ABL2 (ARG)ACTN4AFDNAFF1AFF3AFF4AGGF1ANLNASNSATF7IPAUTS2BCL9BCRBTBD18CASC5CREBBP (CBP)CSF1RDDX3XEBF1ELLELNEML1EP300EPS15ESRRBETV6EWSR1FGFR1FGFR1OPFLT3FOXO4FOXP1FRYLGAS7GPHNHLFHNRNPUL1INPP5DJAK2KMT2AKMT2ELNP1MAML2MEF2DMLLT1MLLT10MLLT3MN1MNX1MYBMYCNCOA2NOTCH1NUP214NUP98P2RY8PAX5PBX1PCM1PDGFRBPICALMPMLPRDM16RAP1GDS1RARARCSD1RUNX1 (AML1)SALL2SETSFPQSPI1SSBP2STILSTMN1TAF15TAL1TCF3TCF7TET1USP9XZBTB16ZMIZ1ZMYM2ZNF384ZNF521ATMBRAFCDKN2A (P16INK4A)CREBBP (CBP)CSF3R (GM-CSFR)DNM2EGFR (ERBB1)FBXW7GATA2HRASMAP2K1MLH1PAX5PDGFRAPTENSMARCB1
Acute Myeloid Leukemia (AML)
ABI1ABI2ABL1AFDNAFF1AFF4ALKANLNARHGAP26ARHGEF12BCORBCRCASC5CBFA2T3CBFBCBLCCDC88CCEP170BCHD1CHIC2CREBBP (CBP)DAB2IPDDX10DEKDHHELLEP300EPS15ERGETV6FGFR1FIP1L1FLNAFNBP1FOXO3FOXO4FRYLFUSGAS7GATA1GLIS2GPHNHAUS1HOXA9HOXC11HOXC13HOXD13IRF2BP2JAK2KAT6AKDM5AKIAA1524KMT2ALASP1LNP1LPPLYNMAML2MECOMMKL1MLF1MLLT1MLLT10MLLT11MLLT3MLLT6MN1MNX1MYBMYH11MYO1FNCKIPSDNCOA2NF1NPM1NSD1NTRK3NUMA1NUP214NUP98PBX1PCM1PDGFRAPDGFRBPDS5APHF23PICALMPMLPRDM16PRRX1PSIP1PTPRRRANBP2RARARBM15RHEBL1RPL22RPN1RUNX1 (AML1)RUNX1T1SARNPSEPT2SEPT5SEPT6SEPT9SETSH3GL1SORBS2STAT5BTAF15TCF3TET1TFGTOP1TOP3ATRIP11UBA2USP42WHSC1L1WTIPZBTB16ZFYVE19ZNF384ASXL1ATMBCORBRAFCDKN2A (P16INK4A)CHEK2 (RAD53)CREBBP (CBP)CSF3R (GM-CSFR)DAXXDNM2FLT3GATA2IDH1IDH2JAK1JAK3KIT (CD117)KMT2DKRASMAP2K1MPLMYCNRASPBRM1PDGFRAPPM1DPTENPTPN11RAD21RETRUNX1 (AML1)SMARCB1SRSF2U2AF1WT1
Acute Myelomonocytic Leukemia (AMML)
FLNAHOXD13NUP98
B-Cell Acute Lymphoblastic Leukemia (B-ALL)
ABL1ACTN4AFF1AFF3AFF4ATF7IPBCRBTBD18EPS15ERGESRRBETV6EWSR1FUSGAS7JAK2KMT2AMAPRE1MLLT1NUP214P2RY8PAX5PBX1PCM1RUNX1 (AML1)SETSSBP2TCF3USP9XZNF384ZNF521
Blast Phase Chronic Myeloid Leukemia
ABL1BCRETV6JAK2
Chronic Eosinophilic Leukemia
ACSL6TNIP1
Chronic Lymphocytic Leukemia (CLL)
MYCNOTCH1BRAFCHEK2 (RAD53)CSF3R (GM-CSFR)MAP2K1TERT
Chronic Myeloid Leukemia (CML)
ABL1BCRCCDC88CETV6JAK2MECOMMN1NDE1NUP98PCM1PDGFRBRUNX1 (AML1)ABL1CDKN2A (P16INK4A)CREBBP (CBP)CSF3R (GM-CSFR)FBXW7GATA2
Chronic Myelomonocytic Leukemia (CMML)
CREBBP (CBP)ELLETV6KMT2AMN1CSF3R (GM-CSFR)HRASSRSF2
Myelodysplastic Syndromes (MDS)
ABL1ACTN4ALKCASC5CREBBP (CBP)DEKERGETV6FRYLFUSHOXD13JAK2KMT2ALNP1MAML2MECOMMLF1MN1MNX1NDE1NPM1NUP214NUP98PCM1PDGFRBPRDM16PTPRRRANBP2RUNX1 (AML1)RUNX1T1TOP1CDKN2A (P16INK4A)CSF3R (GM-CSFR)ETNK1GNASHRASRAD21SETBP1SRSF2U2AF1XPO1ZRSR2
Myeloproliferative Neoplasms
ABL1ACSL6BCRETV6FGFR1FGFR1OPFIP1L1FLT3HOXA9HOXD13JAK2LYNMECOMMLF1MN1NPM1NUP98PDGFRBPRKG2PSIP1RARARUNX1 (AML1)TNIP1ZMYM2ABL1ASXL1JAK2JAK3KRASMPLNRASSETBP1SF3B1SH2B3SRSF2
T-Cell Acute Lymphoblastic Leukemia (T-ALL)
ABL1AFDNAGGF1ASNSBCRCASC5DDX3XETV6JAK2KMT2AKMT2EMLLT1MLLT10NOTCH1NUP214PBX1RUNX1 (AML1)SALL2SETSPI1STILSTMN1TAL1TCF3TCF7
Other Leukemias
IKZF3IRF2BP2MYCNPM1PDCD1LG2SETD2
Commercial Control Samples
ALKBAIAP2L1BRAFCCDC6CD74EGFR (ERBB1)EML4ERGETV6FGFR3KIF5BLMNAMETNCOA4NTRK1NTRK3PAX8PPARGRETROS1SEPT14SLC34A2SLC45A3TACC3TFGTMPRSS2TPM3
General Leukemia Markers
ANPEPCD19CD200CD33CD34CD38CR2FOXM1FOXO3HOXA9ITGA6KIT (CD117)MS4A1RUNX1 (AML1)
Leukemia Subtype Marker
Acute Lymphoblastic Leukemia (ALL)​
ANPEPBTG1CASP8AP2CD19CD1ACD2CD22CD33CD5CD7CD79ACD8ACR2ETV6HLA-DRAHLA-DRB1IL2RA (CD25)JUNKIT (CD117)LMO1LMO2LYL1MEIS1MMEMS4A1MYCPBX1PTPRCRB1VEGFAWT1
B Cell Acute Lymphoblastic Leukemia (B-ALL)​
BTG1CD300ACD72CD79ACD79BCD86CDKN2A (P16INK4A)CDKN2B (p15INK4b)CRLF2 (TSLPR)EBF1ETV6HOXA9IKZF1PAX5RB1
T Cell Acute Lymphoblastic Leukemia (T-ALL)​
BTKCD27 (TNFRSF7)CD4KCNN4LMO1LMO2LYL1MMP9RUNX1 (AML1)SERPINI1TAL1THBS1 (TSP-1)TLX1TLX3VPREB3
Acute Myeloid Leukemia (AML)​
ADGRE5 (CD97)ASS1BAALCBCL11BBIRC5CD200CD300ACD44CD86CD96CD99CLEC12AERGFCGR2AFLT3HAVCR2IL2RA (CD25)JUNKIT (CD117)KLF4LEF1MECOMMEIS1MMP9NPM1PTPRCTHBS1 (TSP-1)VEGFAWT1
Chronic Lymphocytic Leukemia (CLL)​
ABCA6AIM2AKT1BAXBCL2BIRC2 (c-IAP1)BTKCD19CD200CD24CD27 (TNFRSF7)CD5CD79BCXCR4IL7ITGA4 (CD49D)ITGAMJUNKCNN4LAIR1LEF1MCL1MMP9MS4A1ROR1SERPINI1SOX11THBS1 (TSP-1)TNFTTNVEGFAVPREB3WNT3
Chronic Myeloid Leukemia (CML)​
AURKAAURKBIL2RA (CD25)JUNKIT (CD117)PTCH1PTPRC
Other Leukemia Subtypes​
CD72IL2RA (CD25)SPI1
Leukemia Stem Cell & Proliferation Markers
ADGRG1BAALCBMI1CD33CD34CD44CD47CD96CD99CLEC12ACXCL12 (SDF1)CXCR4ERGFCGR2AHAVCR2IL2RA (CD25)IL3RAKIT (CD117)KLF4LAIR1LIN28AMYCPOU5F1 (OCT4)PTPRCSOX2THY1WT1
Possible Prognostic Significance
Indicator of Clinical Outcome in Leukemia​
AURKBBAALCBIRC5ERGFOXO3GATA2MECOMMEIS1RUNX1 (AML1)SPI1WT1
Acute Lymphoblastic Leukemia (ALL)​
ABCB1 (MDR1, PGY1)AKT1ANPEPBIRC5CD33CD3DCD44FLT3HOXA9IKZF1JUNMMEMYCPAX5SMYD2
B Cell Acute Lymphoblastic Leukemia (B-ALL)​
ANPEPCD33CRLF2 (TSLPR)JUNMS4A1
T Cell Acute Lymphoblastic Leukemia (T-ALL)​
BCL11BBMI1LMO1LMO2LYL1MYCTAL1TLX1TLX3
Acute Myeloid Leukemia (AML)​
ABCB1 (MDR1, PGY1)ANGPT2BAALCBCL2BIRC2 (c-IAP1)BIRC5BMI1CCNA1CD200CD34CD4CD44CD47CD96CLEC12ACXCL12 (SDF1)CXCR4ERGGATA2HAVCR2HGFIL2RA (CD25)IL3RAKLF4LEF1MECOMMEIS1MN1MYCRUNX1 (AML1)SOX11SOX2SPI1WT1XIAP
Chronic Lymphocytic Leukemia (CLL)​
ABCA6ANGPT2BCL2CD24CD38CD69ITGA4 (CD49D)KCNN4LAIR1LPLMS4A1MYCNOTCH1ROR1SOX11TTNUGT2B17VPREB3WNT3ZAP70
Chronic Myeloid Leukemia (CML)​
AURKAAURKBLIN28AMCL1PTCH1
Chemotherapy Resistance Related​
AKT1AURKBBAALCBCL2BIRC2 (c-IAP1)CD274 (PD-L1)CD274 (PD-L1)CD44CD47ERGHLA-DRAHLA-DRB1IL3RAMCL1MYCXIAP
Hypoxia & Oxidative Stress Related​
ANGPT2VEGFA
Treatment Target or Treatment Indicator​
ASS1BMI1CASP8AP2CD33CD47CD69CD96CDC25ACDKN2A (P16INK4A)CDKN2B (p15INK4b)CLEC12ACXCR4FLT3FOXM1FOXO3HAVCR2IL3RAITGAMKLF4LMO2MS4A1MYCPTCH1SERPINI1SMARCA4TAL1ZAP70
Associated with Invasiveness or Infiltration into Central Nervous System​
CXCL12 (SDF1)CXCR4ZAP70
Minimal Residual Disease​
ADGRE5 (CD97)BAALCBCL2CD19CD200CD24CD300ACD44CD47CD69CD72CD79BCD86CD99CLEC12AHAVCR2IL2RA (CD25)IL3RAITGA6NPM1PBX1WT1
Mechanistic Role in Pathogenesis
BCL11BBCL2BMI1ERGFOXM1GATA2HOXA9LMO2LPLMEIS1NOTCH1PAX5SPI1TAL1TLX1TLX3TNFVEGFAWT1
Expression Altered due to Genetic Alterations
Acute Lymphoblastic Leukemia (ALL)​
AHI1BCL11ABCL2BCL9BRD4CCND2CEBPACEBPBCEBPDCEBPECEBPGCRLF2 (TSLPR)EPORETV6HOXA1ID4IGF2BP1IL3IRS4LCKLHX4LMO1LMO2LYL1MYBMYCNKX2-5NOTCH1OLIG2TAL2TLX1TLX3
Acute Myeloid Leukemia (AML)​
MECOMNKX2-5RANBP17TCL1ATLX3
Other Leukemia Subtypes & Other Genetic Alterations​
BAALCBCL11BCRLF2 (TSLPR)ERGKIT (CD117)LMO1LPLNPM1TAL1ZAP70
Chronic Neutrophilic Leukemia (CNL)
CSF3R (GM-CSFR)
Multiple Myeloma
ATMBRAFCDKN2A (P16INK4A)EGFR (ERBB1)FBXW7HRASMYCPTENSMARCB1
Myelofibrosis
CHEK2 (RAD53)IDH1IDH2SRSF2
Myeloid Malignancies
CBLCBLBDNMT3AEZH2
Other Myeloid Neoplasms
BRAFCDKN2A (P16INK4A)CUX1FBXW7HRASMYD88PTENSTAT3

Product Resources

icon_0041_download-s Download Target List
icon_0041_download-s Detailed Target List for each Analyte
File Size: 30.85 KBLanguage: English

Resources

Brochures & Guides (2)
Massively Parallel Sequencing Solutions for Human Identity
PDF (2MB)

Next-generation sequencing using QIAGEN’s QIAseq – a powerful tool for human identification


The QIAseq advantage – interactive product profile
PDF (2MB)
State-of-the-art technologies to fast-track and streamline NGS workflows
Application Notes (2)
Noninvasive prenatal paternity testing by means of SNP-based targeted sequencing barcoded with Unique Molecular Indices
PDF (435KB)

The use of UMIs as part of a QIAseq targeted sequencing panel

QIAseq SPE technology for Illumina: Redefining amplicon sequencing
PDF (238KB)
Safety Data Sheets (2)
Safety Data Sheets
Download Safety Data Sheets for QIAGEN product components.
QIAseq 8-UDI Kit Set D (48)
Kit Handbooks (1)
QIAseq RNA Fusion XP Panel Handbook
PDF (3MB)
Template Files (1)
QIAseq RNA Fusion XP All-in-One Tool
SOFTWARE (884KB)
Certificates of Analysis (1)
Certificates of Analysis
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