Target List
AKT & PI3 Kinase Family Members & Their Regulators
AKT1AKT2AKT3BTKGRB10GRB2HSPB1 (HSP27)ILKMTCP1PDK2PDPK1PIK3CA (p110-alpha)PIK3CGPIK3R1 (p85-ALPHA)PIK3R2 (p85-BETA)PAK1PRKCAPRKCBPRKCZPTENTCL1A
IGF-1 Signaling
CSNK2A1ELK1FOSGRB2HRASIGF1IGF1RIRS1JUNMAP2K1MAPK3 (ERK1)MAPK8 (JNK1)PTPN11RAF1RASA1SHC1SOS1SRF
GSK3 Inactivation & β-Catenin Accumulation
ADARAKT1APCCCND1CD14CTNNB1EIF2AK2GJA1 (CX43)GSK3BIRAK1MYD88NFKB1PDK1TIRAPTLR4TOLLIP
Cytoskeleton Regulators
CDC42PDGFRARAC1RHOAWASL
PTEN-Dependent Cell Cycle Arrest & Apoptosis
AKT1CDKN1B (P27KIP1)FASLG (TNFSF6)FOXO3GRB2ILKITGB1MAPK1 (ERK2)MAPK3 (ERK1)PDK1PDK2PTENPTK2 (FAK)RBL2SHC1SOS1
BAD Phosphorylation & Anti-Apoptotic Pathways
AKT1BADGRB2HRASIGF1RIRS1MAP2K1MAPK1 (ERK2)MAPK3 (ERK1)RAF1RPS6KA1SHC1SOS1YWHAH
mTOR Signaling
AKT1EIF4BEIF4EEIF4EBP1 (4E-BP1)EIF4G1FKBP1A (FKBP12)MTORPDK1PDK2PTENRHEBRPS6KB1TSC1TSC2
Regulation of eIF4e & p70 S6 Kinases
AKT1EIF4EEIF4EBP1 (4E-BP1)EIF4G1MTORIRS1MAPK1 (ERK2)MAPK14 (p38ALPHA)MAPK3 (ERK1)PABPC1PDK1PDK2PRKCAPTEN
Regulation of Adipogenesis
RPS6KB1
Other AKT Signaling Genes
CASP9CHUK (IKKα)FOXO1NFKBIA (IκBα, MAD3)