Target List
MAP Kinase Signaling
ARAFBRAFDLK1MAP3K1 (MEKK1)MAP3K2 (MEKK2)MAP3K3 (MEKK3)MAP3K4 (MEKK4)MAP4K1 (HPK1)MOSMST1PAK1RAF1MAP2K1MAP2K2 (MEK2)MAP2K3 (MEK3)MAP2K4 (MKK4, JNKK1)MAP2K5 (MEK5)MAP2K6 (MEK6, MKK6)MAP2K7 (JNKK2)MAPK1 (ERK2)MAPK3 (ERK1)MAPK6 (ERK3)MAPK7 (ERK7)MAPK8 (JNK1)MAPK9 (JNK2)MAPK10 (JNK3)MAPK11 (p38Beta)MAPK12 (p38GAMMA)MAPK13 (p38delta)MAPK14 (p38ALPHA)
Activated Transcription Factors
ATF2 (CREB2)CREB1CREBBP (CBP)EGFR (ERBB1)ELK1ETS1ETS2JUNMAPKAPK2MAPKAPK3MAXMEF2CMKNK1MYCNFATC4 (NFAT3)PRDX6 (AOP2)SMAD4 (MADH4)TP53 (p53)
Induced by MAP Kinase Signaling
COL1A1EGR1FOSHSPA5 (GRP78)HSPB1 (HSP27)JUNMYCTP53 (p53)
Raf Regulating Proteins
HRASKRASKSR1MAP2K1MAP2K2 (MEK2)NRAS
MEKK1 Interacting Proteins
CDC42CHUK (IKKα)GRB2HRASKRASMAP2K1MAP2K2 (MEK2)MAP2K4 (MKK4, JNKK1)MAP2K7 (JNKK2)MAP4K1 (HPK1)MST1NRASRAC1SFN (14-3-3σ, YWHAS)
Scaffolding & Anchoring Proteins
LAMTOR3 (MP1)MAP3K1 (MEKK1)MAPK8IP2 (JIP-1)
Cell Cycle Proteins Regulated by ERK1/2 Signaling
CCNA1CCNA2CCNB1CCNB2CCND1CCND2CCND3CCNE1CDK2CDK4CDK6CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)CDKN1C (p57Kip2)CDKN2A (P16INK4A)CDKN2B (p15INK4b)CDKN2C (p18-INK4C)CDKN2D (p19-INK4D)E2F1RB1