Target List
p53 Activation
ATMATRBBC3 (PUMA)BRCA1CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)FOXO3GMLMDM2MSH2SIRT1TP63TP73
p53 Regulators & Interactors
CDKN2A (P16INK4A)DNMT1HDAC1KAT2BMDM2MDM4SIRT1TADA3TP53AIP1TP53BP2TP63TP73
p53 Targets
Apoptosis
APAF1BAXBBC3 (PUMA)BTG2CASP9EGFR (ERBB1)EI24ESR1 (ERα)FASPRKCATNFTNFRSF10B (DR5)TP53 (p53)TP53AIP1TP73
Cell Cycle
CCNG1CDC25ACDC25CCDKN1A (p21CIP1, WAF1)E2F1E2F3GMLMDM2MYCPPM1DRB1RPRMSESN2SIAH1
DNA Damage & Repair
BRCA1BTG2EGFR (ERBB1)GADD45APCNAPTTG1
Angiogenesis
ADGRB1 (BAI1)IL6PTEN
Responses Downstream of p53 Signaling
Apoptosis
APAF1BCL2BCL2A1 (BFL1)BIDBIRC5CASP2CASP9CRADDFADDFASLG (TNFSF6)IGF1RMCL1NF1NFKB1PIDD1 (PIDD)RELATNFRSF10DTRAF2WT1
Cell Cycle
CCNB1CCNE1CCNG1CCNHCDK1CDK4PRC1TSC1
DNA Damage & Repair
BRCA2MLH1XRCC5
Transcription Factors & Regulators
BRCA2EGR1JUNMYOD1NFKB1RELASTAT1
Other Responses Downstream of p53 Signaling
HK2KRAS